Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/38307
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dc.contributor.authorŽūkienė, Rasa-
dc.contributor.authorČižas, Paulius-
dc.contributor.authorMaslauskaitė, Sandra-
dc.contributor.authorBanienė, Rasa-
dc.contributor.authorMildažienė, Vida-
dc.coverage.spatialGB-
dc.date.accessioned2018-10-06T14:51:59Z-
dc.date.available2018-10-06T14:51:59Z-
dc.date.issued2006-
dc.identifier.issn1742464X-
dc.identifier.otherVDU02-000005478-
dc.identifier.urihttp://www3.interscience.wiley.com/cgi-bin/fulltext/118635183/PDFSTART-
dc.description31st Congress of the Federation-of-European-Biochemical-Societies (FEBS) Istanbul, Turkey, Jun. 24-29, 2006 : meeting abstracts-
dc.description.abstractHyperthermia has high potential as a cancer treatment modality. That implies the need to determine the kinetic response of mitochondria from healthy tissue to moderate heating as well. We have compared the effect of moderate heating on the respiration and NAD(P)H fluorescence in isolated rat heart and liver mitochondria incubated at various Ca2+ concentrations. The rise of temperature from 37 to 42 C caused substantial increase in the inner membrane permeability in both liver and heart mitochondria, but state 3 respiration in heart mitochondria increased by 30% whereas it decreased by 13–23% in liver mitochondria [NAD(P)H fluorescence did not changed in both cases]. The response of liver and heart mitochondria was very different in the range of temperature from 42 to 47 C. Complete uncoupling of oxidative phosphorylation and the inhibition of the respiration was observed at 47 C in isolated heart mitochondria. Respiration was completely ceased in liver mitochondria, indicating that their respiratory chain is more susceptible to higher temperature. Increase of temperature to 47 C was followed by NAD(P)H fluorescence decrease both in heart and liver mitochondria. Change of free Ca2+ concentration in incubation medium from granules by A. Galoyan. In the experiments 108 Wistar male rats of 160–200 g mass were used. CS was induced by a compression of femoral soft tissues using a special press. Common amount of calcium ions was defined using crezolphtalein spectrophotometer method. The results show the level of Ca2+ in blood after 2 h compression and 2, 4, 24 and 48 h decompression and under the influence of PRP. After 2 h compression the level of Ca2+ decreases by 21% , and during decompression period the concentration of Ca2+ increases in blood by 20%, 21%, 36%, 47%, accordingly after 2, 4, 24 and 48 h decompression. So, the decompression period after 2 h compression is characterized by the increasing level of Ca2+ in blood.[...]en
dc.description.sponsorshipGamtos mokslų fakultetas-
dc.description.sponsorshipKauno medicinos universitetas-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 77-77-
dc.language.isoen-
dc.relation.ispartofFEBS journal. Oxford : Blackwell Pub., Vol. 273, suppl. 1 (2006)-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyMEDLINE-
dc.subjectMitochondriaen
dc.subjectHyperthermiaen
dc.subjectFluorescenceen
dc.subject.classificationTezės Clarivate Analytics Web of Science / Theses in Clarivate Analytics Web of Science (T1a)-
dc.subject.otherBiologija / Biology (N010)-
dc.titleEffects of hyperthermia on mitochondrial respiration and NAD(P)H fluorescenceen
dc.typeconference paper-
dc.identifier.doihttps://doi.org/10.1111/j.1742-4658.2006.05277.x-
dc.identifier.isiWOS:000238914000258-
dc.date.updated2020-03-23T11:49Z-
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local.typeT-
item.fulltextNo Fulltext-
item.grantfulltextnone-
crisitem.author.deptBiochemijos katedra-
crisitem.author.deptGamtos mokslų fakultetas-
crisitem.author.deptGamtos mokslų fakultetas-
crisitem.author.deptBiochemijos katedra-
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications
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