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  • conference paper ; ;
    Liaudanskas, Mindaugas
    ;
    Žvikas, Vaidotas
    ;
    Viškelis, Pranas
    ;
    Viškelis, Jonas
    ;
    Kaunas : Vytautas Magnus University, 2022
    The plants of Actinidia kolomikta are functionally dioecious so this species is characterized by both male and female flowers [1]. A. kolomikta flowers do not contain nectar and berry yields can be greatly reduced if pollinators do not visit the flowers. On the other hand, various chemical compounds in the flowers can attract pollinators. The aim of this work was to assess the diversity of phenolic compounds in male and female flowers of A. kolomikta. Separation of phenolic compounds was performed with the Acquity H-class UHPLC system (Waters, Santa Clara, CA, USA) equipped with a triple quadrupole tandem mass spectrometer (Xevo, Waters, USA) with an electrospray ionization source (ESI) to obtain MS/MS data using a previously described and validated UHPLC-ESI-MS/MS technique [2]. A total of 14 phenolic compounds were identified both in male and female flowers. Flavonols were the primary class found in flowers, other identified phenolic compounds were flavan-3-ols, phenolic acids and flavones. The major flavonols identified were kaempherol-3-O-glucoside, rutin, kaempherol, isorhamnetin, isorhamnetin-3-O-rutinoside, isorhamnetin-3-O-glucoside, quercetin, and quercitrin. Flavon-3-ols (+)-catechin, (-)-epicatechin, and procyanidin C1 represented the second most abundant class of phenolic compounds. For flavone class, small amounts of apigenin were found. Two compounds belonging to the hydroxycinnamic acids class, i.e., chlorogenic and neochlorogenic acids were detected in both male and female flowers.
  • conference paper ;
    Duburs, Gunars
    ;
    Vilnius : Lietuvos mikrobiologų draugija, 2022
    C. albicans yra įvardijama kaip pagrindinė padermė, sukelianti invazines kandidozes. C. glabrata sukeliamų infekcijų skaičius kasmet didėja dėl atsparumo priešgrybeliniams vaistams. Atsparumas plačiai naudojamiems azolams gali atsirasti dėl įvairių priežasčių, tarp jų ir dėl daugiavaisčio atsparumo siurblių veiklos. Naujų preparatų kūrimas, kitos paskirties medikamentų derinimas su jau žinomais priešgrybeliniais vaistais gali tapti efektyvia priemone, leidžiančia kovoti su patogeninių mielių atsparumu. Tyrimo tikslas – įvertinti naujai susintetintų stirilpiridinų klasės junginių, klinikinėje praktikoje taikomų statinų bei šių preparatų derinių su flukonazolu fungicidinį poveikį Candida mielėms bei žinduolių ląstelėms. Stirilpiridinų, atorvastatino ir flukonazolo fungicidinis poveikis C. albicans ir C. glabrata nustatytas mikroskiedimų metodu, sąveika tarp flukonazolo ir tiriamųjų junginių įvertinta nustatant frakcijos slopinančios koncentracijos indeksą (ΣFIC). Junginių poveikis CHO-K1 ląstelių gyvybingumui vertintas XTT metodu. Nustatyta, kad 0,06-8 μg/ml koncentracijų intervale stirilpiridinai efektyviai slopino C. albicans augimą, bet C. glabrata ląstelių augimo slopinimui reikėjo didesnių koncentracijų. Atorvastatino poveikis tirtoms Candida ląstelėms buvo panašus: tik 64-128 μg/ml šio junginio visiškai sustabdė augimą. Stipriausias sinerginis poveikis, efektyviai slopinantis Candida augimą, nustatytas taikant flukonazolo derinius su CSDP+ ir atorvastatinu. DEASD+ pasižymėjo didžiausiu citotoksiškumu: 2 μg/ml koncentracija visiškai nuslopino CHO-K1 ląstelių gyvybingumą. Gauti rezultatai rodo, kad stirilpiridinai ir statinai galėtų būti perspektyvūs adjuvantai, efektyviai didinantys flukonazolo aktyvumą prieš Candida mieles.
  • Canopy animals are the main carriers of mite distributed pathogens and tanks in Europe. Bison bonasus is the largest wild animal of Europe, which is recorded not only to the Lithuanian Red Book, but also to the International Red Book. For this reason, studies related to tick pathogens in the ticks gathered from animals and from spleen samples are complicated. The aim of this study is to investigate the pathogens of ticks in spleen samples and ticks collected from Bison bonasus in Lithuania. The material was collected in the territory of Lithuania in the period from 2014 year up to 2022 year from the dead (car or train accidents, dead for unknown reasons) or removed from nature by protection plan because of illness or genetic disorders. Following the analysis of the data and the analysis of the sequences found that Babesia divergens and Babesia capreoli were found in spleen samples and in the ticks collected from Bison bonasus were found Babesia divergens and Babesia divergens, Babesia mircoti and Babesia venatorum. Also, in the bison samples and the ticks were found Anaplasma phagocytophilum and Borrelia burgdorferi pathogens.
  • book-chapter ; ;
    Singapore : Springer Nature, 2022
    This chapter reviews the institutionalisation of the qualifications and training of VET teachers in the context of the key critical junctures of the skill formation which have been taking place in Lithuania since 1990. It gives an outline of the institutionalisation of the qualifications and training of VET teachers and trainers within the context of institutional change and development of skill formation in Lithuania as well as the key critical junctures, such as post-communist transformation, access to the EU and the global economic crisis of 2008–2009. This chapter provides an outline of the developments that led to the existing model of VET teachers’ qualification and training, offers an institutional model of VET teachers’ qualification and explores possible scenarios for the future. Institutionalisation of VET teachers’ qualifications in Lithuania has been strongly influenced by post-communist transformation, as well as access to the EU. Accession to the EU promoted a more holistic attitude towards VET policymakers and stakeholders regarding skill formation and qualifications. This enabled more systemic attention to the professionalisation and qualifications of VET teachers. Digitalisation of work processes, competence-based reforms of VET curricula and development of work-based learning approaches increasingly require VET teachers in Lithuania to develop their academic knowledge, professional know-how and skills as well as key skills and competencies. These factors foster dynamic institutional changes in the provision of academic and professional qualifications as well as the continuing professional development of VET teachers and trainers.
  • research article ; ;
    European studies – the review of European law, economics and politics
    The meaning of the general principles of EU law has been broadly developed by the Court of Justice of the European Union; however, for many years it had only limited competence in deciding criminal cases. The principle of direct effect is important for ensuring the efficient functioning of EU law. The aim of this research is to find out if and how this principle affects criminal justice. To reach this objective, the researchers examine how the substance and content of the principle, through the doctrine and the judgments of Court of Justice of the European Union, can influence national criminal law and criminal procedure. Afterwards, the actual impact of EU law on national criminal law is evaluated, taking Lithuania as an example. The analysis reveals that direct application of directives in material criminal law is highly unlikely, while in criminal procedural, law such a possibility is real if EU norms are clear, unconditional, and precise.
Most viewed
  • Šis vadovėlis skiriamas aukštųjų mokyklų socialinių mokslų edukologijos, psichologijos, sociologijos, antropologijos, viešosios komunikacijos, ekonomikos, viešojo administravimo, vadybos ir politikos mokslų krypčių sudijų studentams.
      8526
  • Vadovėlis „Takas“ skirtas B1 lygio lietuvių kalbos gebėjimams ugdyti. Jį sudaro 8 pamokos – „žingsniai“, – apimantys svarbias šiam lygiui leksikos temas ir dalį gramatikos. Ši knyga – rinkinys įvairių žanrų, skirtingo sudėtingumo tekstų, kad tiek studentai, tiek jų mokytojai galėtų lanksčiai, kūrybingai ir efektyviai naudotis pateikta medžiaga. Tekstų įvairovė – bandymas atsižvelgti į skirtingų mokymosi stilių, pomėgių, socialinių sričių ir interesų besimokančiųjų poreikius. Apskritai vadovėlio išeities taškas – autentiški tekstai ir natūrali kalbos vartosena. Knyga gausiai iliustruota paveikslais ir fotografijomis, atspindinčiomis įvairias gyvenimo realijas, apimančias įvairius socialinius bei kultūrinius lietuvių kalbos vartojimo ir gyvenimo aspektus. Kiekvienoje pamokoje galima rasti ir smulkiosios tautosakos bei sakytinės kalbos, neformaliosios kalbos pavyzdžių. Dalis gramatikos taisyklių pateikta pamokose kaip aktyvios užduotys. Daugiau informacijos ir gramatikos taisyklių pateikta gramatikos priedo įklijoje, kuri suskirstyta ne pagal pamokas, o pagal kalbos dalis. Šią informaciją galima naudoti skirtingose pamokose, kai tik kyla klausimų dėl tinkamos žodžio formos. Atmintuke rasite kiekvienos pamokos koliažus, kuriuos galima rodyti išmaniojoje lentoje interaktyvioms užduotims, klausymo įrašus ir visus vadovėlio tekstus, kad mokytojas panorėjęs galėtų išradingai juos panaudoti kurdamas savo užduotis. Pajuskite, kaip žingsnis po žingsnio lietuvių kalba ir kultūra jums tampa suprantamesnė, įdomesnė, gal net artimesnė.
      5669  2309
  • book
    Kaunas : Vytauto Didžiojo universiteto leidykla, 2012
    Šiuolaikinei organizacijai, norinčiai sėkmingai dirbti rinkoje, būtinos marketingo komunikacijos. Jos yra vienas pagrindinių šiuolaikinio marketingo aspektų. Tai svarbus bet kokios organizacijos veiklos elementas, leidžiantis organizacijai bendrauti su klientais. organizacijos turi mokėti koordinuoti, integruoti, planuoti savo komunikaciją – išmokti naudoti tokį galingą marketingo įrankį kaip marketingo komunikacijos. Mokomoji knyga parengta remiantis marketingo komunikacijų tema parašytais lietuvių ir užsienio autorių darbais ir vadovėliais, taip pat internetu pasiekiamais šaltiniais.
      5092  15394
  • Publication
    Privačių subjektų surinktų duomenų naudojimas Lietuvos baudžiamajame procese
    [The use of the data collected by the private persons in the Lithuanian criminal procedure]
    research article ;
    Globalizacijos iššūkiai baudžiamajai justicijai : recenzuotų mokslinių straipsnių baudžiamosios teisės, bausmių vykdymo ir baudžiamojo proceso klausimais rinkinys. Vilnius : Registrų centras, 2014, p. 398-412
    The use of the private persons in the collecting of the evidence in the criminal procedure is analysed in this article. The evidence presented from the private persons could be used in the criminal procedure. The article analyses the role of the private persons, evaluation of the evidence collected by the private persons in the court practice, the principles of collecting such evidence are also analysed. The authors analyse the ability to use private detectives in the criminal procedure.
      4430
  • book
    Kaunas : Vytauto Didžiojo universiteto leidykla, 2010
    The book contains the theories and concepts of organizational culture, increase knowledge and understanding of organizational culture terminology, elements, factors, subcultures, socialization and commitment, ethics and social responsibility, multicultural aspects of organization, also managers role, develops students skills in cultural analysis, by providing practice in assessing cultural problems.
      2922  3124
Most downloaded
  • book
    Kaunas : Vytauto Didžiojo universiteto leidykla, 2009
    This teaching aid has grown out from the course Introduction into English Linguistics which I have been teaching at Vytautas Magnus University for a number of years. Its aim is to present students with a concise and up-to-date discussion of some of the main topics that mod-ern linguistics addresses. The teaching guide is provided with exercises for each topic (graded from less difficult to advanced), and questions for discussion. All the exercises have been tested in class. The teaching guide also includes a glossary of the most important terms which stu-dents have to know and be able to use not only in this course but also in the other linguistic courses that they take in the programme of English Philology.
      1948  38573
  • book
    Kaunas : Vytautas Magnus University, 2011
    This text serves as an introduction to critical analysis of crime fiction in English. After a brief review of the pre-history of crime fiction in English, the principal focus is on sub-genres such as Golden Age detective stories, American noir thrillers, thrillers in general and police procedurals. For each sub-genre a list of characteristics is provided. Some major authors like Agatha Christie, Raymond Chandler, P.D. James, Ruth Rendell, Ian Rankin and Kathy Reichs are given closer attention. In addition, newer trends in crime fiction are discussed. Exercises for students and advice in carrying out research on crime fiction are also given.
      2783  17426
  • book ;
    Kaunas : Vytauto Didžiojo universiteto leidykla, 2011
    Cheminių reakcijų ir procesų termodinamika, grįžtamosios ir negrįžtamosios cheminės reakcijos, fazių pusiausvyra ir tirpalai, elektrochemija, cheminių reakcijų kinetika, koloidų chemija. Šioje knygoje pateikiama teorinė dalis, uždavinių sprendimai, užduotys savarankiškam darbui, laboratorinių darbų aprašai minėtomis temomis.
      1969  16679
  • The idea to write this book primarily came from our intention to share what we have discovered about one of the greatest childhood miracles – play. For a number of years we have explored this phenomenon, yet its profound and extraordinary nature still continues to surprise us. Promotes development and, at the same time, is the greatest achievement of the child. Keeping this in mind, we designed our monograph for a few purposes. First, we wanted to present the results of the three-year project “Development of Self-Regulation in Play” attained in play research laboratory of the Lithuanian University of Educational Sciences. Second, we sought for the first time to discuss in Lithuanian language the theory of play based on cultural – historical psychology. Our objective was to formulate and present the key principles of the development of self-regulation through play activities. Finally, we aimed to describe the steps of practical use of joint (adult-child) play activities that help a child to develop a self-regulatory behavior during play. Why did we choose to focus on the development of self-regulation through play activities? Simply that a large number of worldwide studies show (Elkind, 1982, 2007; Singer, Singer, D’Agostino, DeLong, 2008; Frost, 2010) that children’s imaginary play is vanishing and that their imagination and self-regulation skills have deteriorated. Another observed trend is a clear opposition between play and academic learning (Miller & Almon, 2009; Nicolopoulou, 2010). Surveys reveal that currently selfregulation and executive functions are in the center of researchers’ attention worldwide and are among top ten studies in progress. [...]
      16405  1677
  • book
    Kaunas : Vytauto Didžiojo universiteto leidykla, 2012
    Šiuolaikinei organizacijai, norinčiai sėkmingai dirbti rinkoje, būtinos marketingo komunikacijos. Jos yra vienas pagrindinių šiuolaikinio marketingo aspektų. Tai svarbus bet kokios organizacijos veiklos elementas, leidžiantis organizacijai bendrauti su klientais. organizacijos turi mokėti koordinuoti, integruoti, planuoti savo komunikaciją – išmokti naudoti tokį galingą marketingo įrankį kaip marketingo komunikacijos. Mokomoji knyga parengta remiantis marketingo komunikacijų tema parašytais lietuvių ir užsienio autorių darbais ir vadovėliais, taip pat internetu pasiekiamais šaltiniais.
      5092  15394
Most WOS cited
  • research article
    Eeftens, Marloes
    ;
    Beelen, Rob
    ;
    Hoogh, Kees de
    ;
    Bellander, Tom
    ;
    Cesaroni, Giulia
    ;
    Cirach, Marta
    ;
    Declercq, Christophe
    ;
    ;
    Dons, Evi
    ;
    Nazelle, Audrey de
    ;
    Dimakopoulou, Konstantina
    ;
    Eriksen, Kirsten
    ;
    Falq, Grégoire
    ;
    Fischer, Paul
    ;
    Galassi, Claudia
    ;
    ;
    Heinrich, Joachim
    ;
    Hoffmann, Barbara
    ;
    Jerrett, Michael
    ;
    Keidel, Dirk
    ;
    Korek, Michal
    ;
    Lanki, Timo
    ;
    Lindley, Sarah
    ;
    Madsen, Christian
    ;
    Mölter, Anna
    ;
    Nádor, Gizella
    ;
    Nieuwenhuijsen, Mark
    ;
    Nonnemacher, Michael
    ;
    Pedeli, Xanthi
    ;
    Raaschou-Nielsen, Ole
    ;
    Patelarou, Evridiki
    ;
    Quass, Ulrich
    ;
    Ranzi, Andrea
    ;
    Schindler, Christian
    ;
    Stempfelet, Morgane
    ;
    Stephanou, Euripides
    ;
    Sugiri, Dorothee
    ;
    Tsai, Ming-Yi
    ;
    Yli-Tuomi, Tarja
    ;
    Varró, Mihály J.
    ;
    Vienneau, Danielle
    ;
    Klot, Stephanie von
    ;
    Wolf, Kathrin
    ;
    Brunekreef, Bert
    ;
    Hoek, Gerard
    Environmental science and technology. Washington : American Chemical Society, 2012, vol. 46, iss. 20, p. 11195-11205
    Land Use Regression (LUR) models have been used increasingly for modeling small-scale spatial variation in air pollution concentrations and estimating individual exposure for participants of cohort studies. Within the ESCAPE project, concentrations of PM(2.5), PM(2.5) absorbance, PM(10), and PM(coarse) were measured in 20 European study areas at 20 sites per area. GIS-derived predictor variables (e.g., traffic intensity, population, and land-use) were evaluated to model spatial variation of annual average concentrations for each study area. The median model explained variance (R(2)) was 71% for PM(2.5) (range across study areas 35-94%). Model R(2) was higher for PM(2.5) absorbance (median 89%, range 56-97%) and lower for PM(coarse) (median 68%, range 32- 81%). Models included between two and five predictor variables, with various traffic indicators as the most common predictors. Lower R(2) was related to small concentration variability or limited availability of predictor variables, especially traffic intensity. Cross validation R(2) results were on average 8-11% lower than model R(2). Careful selection of monitoring sites, examination of influential observations and skewed variable distributions were essential for developing stable LUR models. The final LUR models are used to estimate air pollution concentrations at the home addresses of participants in the health studies involved in ESCAPE.
    WOS© Citations 566  107Scopus© Citations 614
  • research article
    Beelen, Rob
    ;
    Hoek, Gerard
    ;
    Vienneau, Danielle
    ;
    Eeftens, Marloes
    ;
    Dimakopoulou, Konstantina
    ;
    Pedeli, Xanthi
    ;
    Tsai, Ming-Yi
    ;
    Künzli, Nino
    ;
    Schikowski, Tamara
    ;
    Marcon, Alessandro
    ;
    Eriksen, Kirsten
    ;
    Raaschou-Nielsen, Ole
    ;
    Stephanou, Euripides G.
    ;
    Patelarou, Evridiki
    ;
    Lanki, Timo
    ;
    Yli-Tuomi, Tarja
    ;
    Declercq, Christophe
    ;
    Falq, Grégoire
    ;
    Stempfelet, Morgane
    ;
    Birk, Matthias
    ;
    Cyrys, Josef
    ;
    Klot, Stephanie von
    ;
    Nádor, Gizella
    ;
    Varró, Mihály J.
    ;
    ; ;
    Mölter, Anna
    ;
    Lindley, Sarah
    ;
    Madsen, Christian
    ;
    Cesaroni, Giulia
    ;
    Ranzi, Andrea
    ;
    Badaloni, Chiara
    ;
    Hoffmann, Barbara
    ;
    Nonnemacher, Michael
    ;
    Krämer, Ursula
    ;
    Kuhlbusch, Thomas
    ;
    Cirach, Marta
    ;
    Nazelle, Audrey de
    ;
    Nieuwenhuijsen, Mark J.
    ;
    Bellander, Tom
    ;
    Korek, Michal
    ;
    Olsson, David
    ;
    Strömgren, Magnus
    ;
    Dons, Evi
    ;
    Jerrett, Michael
    ;
    Fischer, Paul
    ;
    Wang, Meng
    ;
    Brunekreef, Bert
    ;
    Hoogh, Kees de
    Atmospheric environment. Amsterdam, Netherlands : Elsevier B.V., 2013, vol. 72, p. 10-23
    Estimating within-city variability in air pollution concentrations is important. Land use regression (LUR) models are able to explain such small-scale within-city variations. Transparency in LUR model development methods is important to facilitate comparison of methods between different studies. We therefore developed LUR models in a standardized way in 36 study areas in Europe for the ESCAPE (European Study of Cohorts for Air Pollution Effects) project. Nitrogen dioxide (NO2) and nitrogen oxides (NOx) were measured with Ogawa passive samplers at 40 or 80 sites in each of the 36 study areas. The spatial variation in each area was explained by LUR modelling. Centrally and locally available Geographic Information System (GIS) variables were used as potential predictors. A leave-one out cross-validation procedure was used to evaluate the model performance. There was substantial contrast in annual average NO2 and NOx concentrations within the study areas. The model explained variances (R2) of the LUR models ranged from 55% to 92% (median 82%) for NO2 and from 49% to 91% (median 78%) for NOx. For most areas the cross-validation R2 was less than 10% lower than the model R2. Small-scale traffic and population/household density were the most common predictors. The magnitude of the explained variance depended on the contrast in measured concentrations as well as availability of GIS predictors, especially traffic intensity data were important. In an additional evaluation, models in which local traffic intensity was not offered had 10% lower R2 compared to models in the same areas in which these variables were offered. Within the ESCAPE project it was possible to develop LUR models that explained a large fraction of the spatial variance in measured annual average NO2 and NOx concentrations. These LUR models are being used to estimate outdoor concentrations at the home addresses of participants in over 30 cohort studies.
    WOS© Citations 499  115Scopus© Citations 540
  • research article
    Eeftens, Marloes
    ;
    Tsai, Ming-Yi
    ;
    Ampe, Christophe
    ;
    Anwander, Bernhard
    ;
    Beelen, Rob
    ;
    Bellander, Tom
    ;
    Cesaroni, Giulia
    ;
    Cirach, Marta
    ;
    Cyrys, Josef
    ;
    Hoogh, Kees de
    ;
    Nazelle, Audrey de
    ;
    Vocht, Frank de
    ;
    Declercq, Christophe
    ;
    ;
    Eriksen, Kirsten
    ;
    Galassi, Claudia
    ;
    ;
    Grivas, Georgios
    ;
    Heinrich, Joachim
    ;
    Hoffmann, Barbara
    ;
    Iakovides, Minas
    ;
    Ineichen, Alex
    ;
    Katsouyanni, Klea
    ;
    Korek, Michal
    ;
    Krämer, Ursula
    ;
    Kuhlbusch, Thomas
    ;
    Lanki, Timo
    ;
    Madsen, Christian
    ;
    Meliefste, Kees
    ;
    Mölter, Anna
    ;
    Mosler, Gioia
    ;
    Nieuwenhuijsen, Mark
    ;
    Oldenwening, Marieke
    ;
    Pennanen, Arto
    ;
    Probst-Hensch, Nicole
    ;
    Quass, Ulrich
    ;
    Raaschou-Nielsen, Ole
    ;
    Ranzi, Andrea
    ;
    Stephanou, Euripides G.
    ;
    Sugiri, Dorothee
    ;
    Udvardy, Orsolya
    ;
    Vaskövi, Éva
    ;
    Weinmayr, Gudrun
    ;
    Brunekreef, Bert
    ;
    Hoek, Gerard
    Atmospheric environment. Amsterdam, Netherlands : Elsevier B.V., 2012, vol. 62, p. 303-317
    The ESCAPE study (European Study of Cohorts for Air Pollution Effects) investigates relationships between long-term exposure to outdoor air pollution and health using cohort studies across Europe. This paper analyses the spatialvariation of PM2.5, PM2.5absorbance, PM10 and PMcoarseconcentrations between and within 20 study areas across Europe. We measured NO2, NOx, PM2.5, PM2.5absorbance and PM10 between October 2008 and April 2011 using standardized methods. PMcoarse was determined as the difference between PM10 and PM2.5. In each of the twenty study areas, we selected twenty PM monitoring sites to represent the variability in important air quality predictors, including population density, traffic intensity and altitude. Each site was monitored over three 14-day periods spread over a year, using Harvard impactors. Results for each site were averaged after correcting for temporal variation using data obtained from a reference site, which was operated year-round. Substantial concentration differences were observed between and within study areas. Concentrations for all components were higher in Southern Europe than in Western and Northern Europe, but the pattern differed per component with the highest average PM2.5concentrations found in Turin and the highest PMcoarse in Heraklion. Street/urban background concentration ratios for PMcoarse (mean ratio 1.42) were as large as for PM2.5absorbance (mean ratio 1.38) and higher than those for PM2.5 (1.14) and PM10 (1.23), documenting the importance of non-tailpipe emissions. Correlations between components varied between areas, but were generally high between NO2 and PM2.5absorbance (average R2 = 0.80). Correlations between PM2.5 and PMcoarse were lower (average R2 = 0.39). Despite high correlations, concentration ratios between components varied, e.g. the NO2/PM2.5 ratio varied between 0.67 and 3.06. [...]
    WOS© Citations 311  108
  • research article ;
    Energy Conversion and Management. , 2006, Vol. 47, p. 1954-1967
    WOS© Citations 293  48
  • research article
    Triguero-Mas, Margarita
    ;
    Dadvand, Payam
    ;
    Cirach, Marta
    ;
    Martinez, David
    ;
    Medina, Antonia
    ;
    Mompart, Anna
    ;
    Basagaña, Xavier
    ;
    ;
    Nieuwenhuijsen, Mark J.
    Environment international. Amsterdam, Netherlands : Elsevier B.V., 2015, vol. 77, p. 35-41
    Background: Evidence is growing for the beneficial impacts of natural outdoor environments on health. However, most of the evidence has focused on green spaces and little evidence is available on health benefits of blue spaces and about possible mediators and modifiers of such impacts. We investigated the association between natural outdoor environments (separately for green and blue spaces) and health (general and mental) and its possible mediators and modifiers. Methods: Cross-sectional data fromadults interviewed in Catalonia (Spain) between 2010 and 2012 as part of the Catalonia Health Surveywere used. The collected data included sociodemographic characteristics, self-perceived general health, mental health, physical activity and social support. Indicators of surrounding greenness and access to natural outdoor environments within 300 m of the residence and degree of urbanization were derived for residential addresses. Associations were estimated using logistic regression and negative binominal models. Results: Green spaces were associated with better self-perceived general health and better mental health, independent of degree of urbanization. The associationsweremore consistent for surrounding greenness than for access to green spaces. The results were consistent for different buffers, and when stratifying for socioeconomic status. Slightly stronger associations were found for women and residents of non-densely populated areas. No association was found between green spaces and social contacts and physical activity. The results for blue spaces were not conclusive. Conclusion: Green spaces are associated with better general and mental health across strata of urbanization, socioeconomic status, and genders. Mechanisms other than physical activity or social support may explain these associations.
    WOS© Citations 280  93Scopus© Citations 316
Most SCOPUS cited
  • research article ;
    Laprie, Jean-Claude
    ;
    Randell, Brian
    ;
    Landwehr, C.
    IEEE transactions on dependable and secure computing. New York, NY : IEEE Press, Vol. 1, iss. 1, 2004, p. 11-33
    This paper gives the main definitions relating to dependability, a generic concept including as special case such attributes as reliability, availability, safety, integrity, maintainability, etc. Security brings in concerns for confidentiality, in addition to availability and integrity. Basic definitions are given first. They are then commented upon, and supplemented by additional definitions, which address the threats to dependability and security (faults, errors, failures), their attributes, and the means for their achievement (fault prevention, fault tolerance, fault removal, fault forecasting). The aim is to explicate a set of general concepts, of relevance across a wide range of situations and, therefore, helping communication and cooperation among a number of scientific and technical communities, including ones that are concentrating on particular types of system, of system failures, or of causes of system failures.
      108Scopus© Citations 3447
  • research article
    Eeftens, Marloes
    ;
    Beelen, Rob
    ;
    Hoogh, Kees de
    ;
    Bellander, Tom
    ;
    Cesaroni, Giulia
    ;
    Cirach, Marta
    ;
    Declercq, Christophe
    ;
    ;
    Dons, Evi
    ;
    Nazelle, Audrey de
    ;
    Dimakopoulou, Konstantina
    ;
    Eriksen, Kirsten
    ;
    Falq, Grégoire
    ;
    Fischer, Paul
    ;
    Galassi, Claudia
    ;
    ;
    Heinrich, Joachim
    ;
    Hoffmann, Barbara
    ;
    Jerrett, Michael
    ;
    Keidel, Dirk
    ;
    Korek, Michal
    ;
    Lanki, Timo
    ;
    Lindley, Sarah
    ;
    Madsen, Christian
    ;
    Mölter, Anna
    ;
    Nádor, Gizella
    ;
    Nieuwenhuijsen, Mark
    ;
    Nonnemacher, Michael
    ;
    Pedeli, Xanthi
    ;
    Raaschou-Nielsen, Ole
    ;
    Patelarou, Evridiki
    ;
    Quass, Ulrich
    ;
    Ranzi, Andrea
    ;
    Schindler, Christian
    ;
    Stempfelet, Morgane
    ;
    Stephanou, Euripides
    ;
    Sugiri, Dorothee
    ;
    Tsai, Ming-Yi
    ;
    Yli-Tuomi, Tarja
    ;
    Varró, Mihály J.
    ;
    Vienneau, Danielle
    ;
    Klot, Stephanie von
    ;
    Wolf, Kathrin
    ;
    Brunekreef, Bert
    ;
    Hoek, Gerard
    Environmental science and technology. Washington : American Chemical Society, 2012, vol. 46, iss. 20, p. 11195-11205
    Land Use Regression (LUR) models have been used increasingly for modeling small-scale spatial variation in air pollution concentrations and estimating individual exposure for participants of cohort studies. Within the ESCAPE project, concentrations of PM(2.5), PM(2.5) absorbance, PM(10), and PM(coarse) were measured in 20 European study areas at 20 sites per area. GIS-derived predictor variables (e.g., traffic intensity, population, and land-use) were evaluated to model spatial variation of annual average concentrations for each study area. The median model explained variance (R(2)) was 71% for PM(2.5) (range across study areas 35-94%). Model R(2) was higher for PM(2.5) absorbance (median 89%, range 56-97%) and lower for PM(coarse) (median 68%, range 32- 81%). Models included between two and five predictor variables, with various traffic indicators as the most common predictors. Lower R(2) was related to small concentration variability or limited availability of predictor variables, especially traffic intensity. Cross validation R(2) results were on average 8-11% lower than model R(2). Careful selection of monitoring sites, examination of influential observations and skewed variable distributions were essential for developing stable LUR models. The final LUR models are used to estimate air pollution concentrations at the home addresses of participants in the health studies involved in ESCAPE.
    WOS© Citations 566  107Scopus© Citations 614
  • research article
    Beelen, Rob
    ;
    Hoek, Gerard
    ;
    Vienneau, Danielle
    ;
    Eeftens, Marloes
    ;
    Dimakopoulou, Konstantina
    ;
    Pedeli, Xanthi
    ;
    Tsai, Ming-Yi
    ;
    Künzli, Nino
    ;
    Schikowski, Tamara
    ;
    Marcon, Alessandro
    ;
    Eriksen, Kirsten
    ;
    Raaschou-Nielsen, Ole
    ;
    Stephanou, Euripides G.
    ;
    Patelarou, Evridiki
    ;
    Lanki, Timo
    ;
    Yli-Tuomi, Tarja
    ;
    Declercq, Christophe
    ;
    Falq, Grégoire
    ;
    Stempfelet, Morgane
    ;
    Birk, Matthias
    ;
    Cyrys, Josef
    ;
    Klot, Stephanie von
    ;
    Nádor, Gizella
    ;
    Varró, Mihály J.
    ;
    ; ;
    Mölter, Anna
    ;
    Lindley, Sarah
    ;
    Madsen, Christian
    ;
    Cesaroni, Giulia
    ;
    Ranzi, Andrea
    ;
    Badaloni, Chiara
    ;
    Hoffmann, Barbara
    ;
    Nonnemacher, Michael
    ;
    Krämer, Ursula
    ;
    Kuhlbusch, Thomas
    ;
    Cirach, Marta
    ;
    Nazelle, Audrey de
    ;
    Nieuwenhuijsen, Mark J.
    ;
    Bellander, Tom
    ;
    Korek, Michal
    ;
    Olsson, David
    ;
    Strömgren, Magnus
    ;
    Dons, Evi
    ;
    Jerrett, Michael
    ;
    Fischer, Paul
    ;
    Wang, Meng
    ;
    Brunekreef, Bert
    ;
    Hoogh, Kees de
    Atmospheric environment. Amsterdam, Netherlands : Elsevier B.V., 2013, vol. 72, p. 10-23
    Estimating within-city variability in air pollution concentrations is important. Land use regression (LUR) models are able to explain such small-scale within-city variations. Transparency in LUR model development methods is important to facilitate comparison of methods between different studies. We therefore developed LUR models in a standardized way in 36 study areas in Europe for the ESCAPE (European Study of Cohorts for Air Pollution Effects) project. Nitrogen dioxide (NO2) and nitrogen oxides (NOx) were measured with Ogawa passive samplers at 40 or 80 sites in each of the 36 study areas. The spatial variation in each area was explained by LUR modelling. Centrally and locally available Geographic Information System (GIS) variables were used as potential predictors. A leave-one out cross-validation procedure was used to evaluate the model performance. There was substantial contrast in annual average NO2 and NOx concentrations within the study areas. The model explained variances (R2) of the LUR models ranged from 55% to 92% (median 82%) for NO2 and from 49% to 91% (median 78%) for NOx. For most areas the cross-validation R2 was less than 10% lower than the model R2. Small-scale traffic and population/household density were the most common predictors. The magnitude of the explained variance depended on the contrast in measured concentrations as well as availability of GIS predictors, especially traffic intensity data were important. In an additional evaluation, models in which local traffic intensity was not offered had 10% lower R2 compared to models in the same areas in which these variables were offered. Within the ESCAPE project it was possible to develop LUR models that explained a large fraction of the spatial variance in measured annual average NO2 and NOx concentrations. These LUR models are being used to estimate outdoor concentrations at the home addresses of participants in over 30 cohort studies.
    WOS© Citations 499  115Scopus© Citations 540
  • research article
    Pedersen, Marie
    ;
    Giorgis-Allemand, Lise
    ;
    Bernard, Claire
    ;
    Aguilera, Inmaculada
    ;
    Nybo Andersen, Anne Marie
    ;
    Ballester, Ferran
    ;
    Beelen, Rob M. J.
    ;
    Chatzi, Leda
    ;
    Cirach, Marta
    ;
    ; ;
    Eijsden, Manon van
    ;
    Estarlich, Marisa
    ;
    Fernández-Somoano, Ana
    ;
    Fernández, Mariana F.
    ;
    Forastiere, Francesco
    ;
    Gehring, Ulrike
    ;
    Lancet respiratory medicine [elektroninis išteklius]. Amsterdam : Elsevier B.V., 2013, vol. 1, iss. 9, p. 695-704
    Methods. We pooled data from 14 population-based mother–child cohort studies in 12 European countries. Overall, the study population included 74 178 women who had singleton deliveries between Feb 11, 1994, and June 2, 2011, and for whom information about infant birthweight, gestational age, and sex was available. The primary outcome of interest was low birthweight at term (weight <2500 g at birth after 37 weeks of gestation). Mean concentrations of particulate matter with an aerodynamic diameter of less than 2•5 μm (PM2•5), less than 10 μm (PM10), and between 2•5 μm and 10 μm during pregnancy were estimated at maternal home addresses with temporally adjusted land-use regression models, as was PM2•5 absorbance and concentrations of nitrogen dioxide (NO2) and nitrogen oxides. We also investigated traffic density on the nearest road and total traffic load. We calculated pooled effect estimates with random-effects models. Findings. A 5 μg/m3 increase in concentration of PM2•5 during pregnancy was associated with an increased risk of low birthweight at term (adjusted odds ratio [OR] 1•18, 95% CI 1•06–1•33). An increased risk was also recorded for pregnancy concentrations lower than the present European Union annual PM2•5 limit of 25 μg/m3 (OR for 5 μg/m3 increase in participants exposed to concentrations of less than 20 μg/m3 1•41, 95% CI 1•20–1•65). PM10 (OR for 10 μg/m3 increase 1•16, 95% CI 1•00–1•35), NO2 (OR for 10 μg/m3 increase 1•09, 1•00–1•19), and traffic density on nearest street (OR for increase of 5000 vehicles per day 1•06, 1•01–1•11) were also associated with increased risk of low birthweight at term. The population attributable risk estimated for a reduction in PM2•5 concentration to 10 μg/m3 during pregnancy corresponded to a decrease of 22% (95% CI 8–33%) in cases of low birthweight at term. [...].
      113Scopus© Citations 390
  • research article
    Triguero-Mas, Margarita
    ;
    Dadvand, Payam
    ;
    Cirach, Marta
    ;
    Martinez, David
    ;
    Medina, Antonia
    ;
    Mompart, Anna
    ;
    Basagaña, Xavier
    ;
    ;
    Nieuwenhuijsen, Mark J.
    Environment international. Amsterdam, Netherlands : Elsevier B.V., 2015, vol. 77, p. 35-41
    Background: Evidence is growing for the beneficial impacts of natural outdoor environments on health. However, most of the evidence has focused on green spaces and little evidence is available on health benefits of blue spaces and about possible mediators and modifiers of such impacts. We investigated the association between natural outdoor environments (separately for green and blue spaces) and health (general and mental) and its possible mediators and modifiers. Methods: Cross-sectional data fromadults interviewed in Catalonia (Spain) between 2010 and 2012 as part of the Catalonia Health Surveywere used. The collected data included sociodemographic characteristics, self-perceived general health, mental health, physical activity and social support. Indicators of surrounding greenness and access to natural outdoor environments within 300 m of the residence and degree of urbanization were derived for residential addresses. Associations were estimated using logistic regression and negative binominal models. Results: Green spaces were associated with better self-perceived general health and better mental health, independent of degree of urbanization. The associationsweremore consistent for surrounding greenness than for access to green spaces. The results were consistent for different buffers, and when stratifying for socioeconomic status. Slightly stronger associations were found for women and residents of non-densely populated areas. No association was found between green spaces and social contacts and physical activity. The results for blue spaces were not conclusive. Conclusion: Green spaces are associated with better general and mental health across strata of urbanization, socioeconomic status, and genders. Mechanisms other than physical activity or social support may explain these associations.
    WOS© Citations 280  93Scopus© Citations 316

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