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Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Slapšytė, Gražina;Dedonytė, Veronika;Adomėnienė, Aušra;Lazutka, Juozas Rimantas;Kazlauskaitė, Jūratė;Ragažinskienė, Ona;Venskutonis, Petras Rimantas
Title: Genotoxic properties of Betonica officinalis, Gratiola officinalis, Vincetoxicum luteum and Vincetoxicum hirundinaria extracts
Is part of: Food and chemical toxicology. New York : Elsevier Ltd., 2019, Vol. 134
Extent: p. 1-10
Date: 2019
Note: article no. 110815
Keywords: Betonica officinalis;Gratiola officinalis;Vincetoxicum luteum;Vincetoxicum hirundinaria;Antioxidant capacity;Genotoxicity
Abstract: Genotoxicity of B. officinalis, G. officinalis, V. luteum and V. hirundinaria extracts, which demonstrated strong antioxidant capacity, was tested using chromosome aberration, sister chromatid exchange (SCE), cytokinesisblock micronucleus and alkaline single-cell gel electrophoresis (comet) assays in human lymphocytes in vitro and Ames Salmonella/microsome test. All tested extracts were not mutagenic in S. typhimurium strains TA98 and TA100 with and without metabolic activation and did not induce chromosome aberrations in human lymphocytes in vitro. Extract from G. officinalis was the only one, which induced significant increase in micronuclei, indicating possible aneugenic effect. All investigated plant extracts induced DNA damage evaluated by the comet assay, while B. officinalis and V. luteum extracts induced slight increase in SCE values. The determined variation in response might be due to the plant extract tested and donor susceptibility
Affiliation(s): Botanikos sodas
Kauno technologijos universitetas
Vaistinių ir prieskon. augalų kol. Sektorius
Vilniaus universitetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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