During high-intensity exercise, many biochemical reactions and physiological processes take place in the body of athletes, which can lead to hyperbilirubinemia. Therefore, specialists in medicine, biochemistry and sports are constantly looking for laboratory markers that can accurately reflect the metabolic changes that occur due to exercise in various systems, organs and tissues of the body. One such factor that determines an athlete’s functions, his state of health, and his quality of life is the link between bilirubin metabolism in the body. Bilirubin (latbilium – pigment, ruber – red) is a pigment of liver and bile activity formed by the breakdown of erythrocytes, myoglobin. The literature indicates that bilirubin levels increase in the blood during highintensity exercise. Factors contributing to this phenomenon include muscle microtrauma syndrome, erythrocyte hemolysis, functional anemia, exacerbating acidosis, and protein deficiency. Increasing blood acidity during exercise reduces binding to albumin and this promotes an increase in bilirubin IX-alpha, which has toxic effects. The degree of expression of these signs, in turn, depends on the athlete’s body’s adaptation to the level of physical activity. One way to reduce hyperbiliribinaemia to help maintain physical function is to use substances that maintain liver function. Immunomodulatory agents, substances that promote the transport of oxygen to the muscles, maintain the condition of erythrocyte membranes, might be of use. Although the effects of food supplements on the human body are widely studied, there is still insufficient research to confirm the effectiveness of each food supplement. Very few such studies have been performed with high performance athletes, whose metabolism varies greatly during strenuous exercise.[...]