Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/59987
Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Ekologija ir aplinkotyra / Ecology and environmental sciences (N012)
Author(s): Tamayo-Uria, Ibon;Maitre, Léa;Thomsen, Cathrine;Chatzi, Leda;Siroux, Valérie;Aasvang, Gunn Marit;Agier, Lydiane;Casas, Maribel;Castro, Montserrat de;Haug, Line Småstuen;Heude, Barbara;Gützkow, Kristine Bjerve;Krog, Norun Hjertager;Mason, Dan;McEachan, Rosemary R. C;Meltzer, Helle Margrete;Robinson, Oliver;Roumeliotaki, Theano;Sakhi, Amrit K;Urquiza, Jose;Vafeiadi, Marina;Waiblinger, Dagmar;Warembourg, Charline;Wright, John;Slama, Rémy;Vrijheid, Martine;Basagaña, Xavier;Andrušaitytė, Sandra;Dėdelė, Audrius;Gražulevičienė, Regina;Petravičienė, Inga
Contributor(s): Nieuwenhuijsen, Mark
Title: The early-life exposome: description and patterns in six European countries
Is part of: Environment international. Amsterdam : Elsevier B.V., 2018, vol. 123
Extent: p. 189-200
Date: 2018
Note: This work was supported by the European Commission Seventh Framework Programme (FP7/2007–2013) [grant number: 308333–the HELIX project]
Keywords: Exposome;Environmental exposures;Children;Pregnancy;Early life
Abstract: Characterization of the “exposome”, the set of all environmental factors that one is exposed to from conception onwards, has been advocated to better understand the role of environmental factors on chronic diseases. Here, we aimed to describe the early-life exposome. Specifically, we focused on the correlations between multiple environmental exposures, their patterns and their variability across European regions and across time (pregnancy and childhood periods). We relied on the Human Early-Life Exposome (HELIX) project, in which 87 environmental exposures during pregnancy and 122 during the childhood period (grouped in 19 exposure groups) were assessed in 1301 pregnant mothers and their children at 6–11 years in 6 European birth cohorts. Some correlations between exposures in the same exposure group reached high values above 0.8. The median correlation within exposure groups was >0.3 for many exposure groups, reaching 0.69 for water disinfection by products in pregnancy and 0.67 for the meteorological group in childhood. Median correlations between different exposure groups rarely reached 0.3. Some correlations were driven by cohort-level associations (e.g. air pollution and chemicals). Ten principal components explained 45% and 39% of the total variance in the pregnancy and childhood exposome, respectively, while 65 and 90 components were required to explain 95% of the exposome variability. Correlations between maternal (pregnancy) and childhood exposures were high (>0.6) for most exposures modeled at the residential address (e.g. air pollution), but were much lower and even close to zero for some chemical exposures.[...]
Internet: https://doi.org/10.1016/j.envint.2018.11.067
https://doi.org/10.1016/j.envint.2018.11.067
Affiliation(s): Aplinkotyros katedra
Gamtos mokslų fakultetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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