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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Ekologija ir aplinkotyra / Ecology and environmental sciences (N012)
Author(s): Haug, Line Småstuen;Sakhi, Amrit K;Cequier, Enrique;Casas, Maribel;Maitre, Léa;Basagaña, Xavier;Andrušaitytė, Sandra;Chalkiadaki, Georgia;Chatzi, Leda;Coen, Muireann;Bont, Jeroen de;Dėdelė, Audrius;Ferrand, Joane;Gražulevičienė, Regina;Gonzalez, Juan R;Gützkow, Kristine Bjerve;Keun, Hector C;McEachan, Rosie;Meltzer, Helle Margrete;Petravičienė, Inga;Robinson, Oliver;Saulnier, Pierre-Jean;Slama, Rémy;Sunyer, Jordi;Urquiza, Jose;Vafeiadi, Marina;Wright, John;Vrijheid, Martine;Thomsen, Cathrine
Title: In-utero and childhood chemical exposome in six European mother-child cohorts
Is part of: Environment international. Amsterdam : Elsevier B.V., 2018, vol. 121
Extent: p. 751-763
Date: 2018
Note: The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/ 2007–2013) under grant agreement no 308333 – the HELIX project. Dr. Regina Grazuleviciene received the grant of the Lithuanian Agency for Science Innovation and Technology (No. 31V-77).[...]
Keywords: Exposome;Children;Pregnant women;Mother-child pairs;Early-Life Exposome project
Abstract: Background: Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited. Objectives: To characterize concentrations of a large number of environmental contaminants in pregnant women from Europe and their children, based on chemical analysis of biological samples from mother-child pairs. Methods: We relied on the Early-Life Exposome project, HELIX, a collaborative project across six established population-based birth cohort studies in Europe. In 1301 subjects, biomarkers of exposure to 45 contaminants (i.e. organochlorine compounds, polybrominated diphenyl ethers, per- and polyfluoroalkyl substances, toxic and essential elements, phthalate metabolites, environmental phenols, organophosphate pesticide metabolites and cotinine) were measured in biological samples from children (6–12 years) and their mothers during pregnancy, using highly sensitive biomonitoring methods. Results: Most of the exposure biomarkers had high detection frequencies in mothers (35 out of 45 biomarkers with > 90% detected) and children (33 out of 45 biomarkers with > 90% detected). Concentrations were significantly different between cohorts for all compounds, and were generally higher in maternal compared to children samples. For most of the persistent compounds the correlations between maternal and child concentrations were moderate to high (Spearman Rho > 0.35), while for most non-persistent compounds correlations were considerably lower (Spearman Rho < 0.15). For mercury, PFOS and PFOA a considerable proportion of the samples of both mothers and their children exceeded the HBM I value established by The Human Biomonitoring Commission of the German Federal Environment Agency. [...]
Affiliation(s): Aplinkotyros katedra
Vytauto Didžiojo universitetas
Appears in Collections:1. Straipsniai / Articles
Universiteto mokslo publikacijos / University Research Publications

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