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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Aplinkos inžinerija / Environmental engineering (T004);Ekologija ir aplinkotyra / Ecology and environmental sciences (N012)
Author(s): Casas, Maribel;Basagaña, Xavier;Sakhi, Amrit K;Haug, Line Småstuen;Philippat, Claire;Granum, Berit;Manzano, Cyntia B;Brochot, Celine;Zeman, Florence;Bont, Jeroen de;Andrušaitytė, Sandra;Chatzi, Leda;Donaire-Gonzalez, David;Giorgis-Allemand, Lise;Gonzalez, Juan R;Gracia-Lavedán, Esther;Gražulevičienė, Regina;Kampouri, Mariza;Lyon-Caen, Sarah;Pañella, Pau;Petravičienė, Inga;Robinson, Oliver;Urquiza, Jose;Vafeiadi, Marina;Vernet, Céline;Waiblinger, Dagmar;Wright, John;Thomsen, Cathrine;Slama, Rémy;Vrijheid, Martine
Title: Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children
Is part of: Environment international. Amsterdam : Elsevier B.V., 2018, vol. 121
Extent: p. 561-573
Date: 2018
Note: The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no 308333 – the HELIX project. Dr. Maribel Casas received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128). Dr. Regina Grazuleviciene received the grant of the Lithuanian Agency for Science Innovation and Technology (No. 31V-66). Dr. Juan R Gonzalez is supported by Ministerio de Economía y Competitividad y Fondo Europeo de Desarrollo (MTM2015-68140-R). The pregnant women recruited in Grenoble are part of SEPAGES mother-child cohort, which has been partly funded by a grant from the European Research Council (ERC, consolidator grant #311765-EDOHaD, PI, R. Slama)
Keywords: Phthalate metabolites;Phenols;Organophosphate pesticide metabolites;Pregnancy;Childhood;Intraclass-correlation coefficient
Abstract: Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions. Objectives We evaluated the variability of urinary concentrations of 24 non-persistent chemicals: 10 phthalate metabolites, 7 phenols, 6 organophosphate (OP) pesticide metabolites, and cotinine, between weeks from different pregnancy trimesters in pregnant women, and between days and between seasons in children. Methods 154 pregnant women and 152 children from six European countries were enrolled in 2014–2015. Pregnant women provided three urine samples over a day (morning, midday, and night), for one week in the 2nd and 3rd pregnancy trimesters. Children provided two urines a day (morning and night), over two one-week periods, six months apart. We pooled all samples for a given subject that were collected within a week. In children, we also made four daily pools (combining morning and night voids) during the last four days of the first follow-up week. Pools were analyzed for all 24 metabolites of interest. We calculated intraclass-correlation coefficients (ICC) and estimated the number of pools needed to obtain an ICC above 0.80. Results All phthalate metabolites and phenols were detected in >90% of pools whereas certain OP pesticide metabolites and cotinine were detected in <43% of pools. We observed fair (ICC = 0.40–0.59) to good (0.60–0.74) between-day reliability of the pools of two samples in children for all chemicals. Reliability was poor (<0.40) to fair between trimesters in pregnant women and between seasons in children. For most chemicals, three daily pools of two urines each (for weekly exposure windows) and four weekly pools of 15–20 urines each would be necessary to obtain an ICC above 0.80.[...]
Affiliation(s): Aplinkotyros katedra
Vytauto Didžiojo universitetas
Appears in Collections:1. Straipsniai / Articles
Universiteto mokslo publikacijos / University Research Publications

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