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dc.contributor.authorMaitre, Léa-
dc.contributor.authorBont, Jeroen de-
dc.contributor.authorCasas, Maribel-
dc.contributor.authorRobinson, Oliver-
dc.contributor.authorAasvang, Gunn Marit-
dc.contributor.authorAgier, Lydiane-
dc.contributor.authorAndrušaitytė, Sandra-
dc.contributor.authorBallester, Ferran-
dc.contributor.authorBasagaña, Xavier-
dc.contributor.authorBorràs, Eva-
dc.contributor.authorBrochot, Celine-
dc.contributor.authorBustamante, Mariona-
dc.contributor.authorCarracedo, Angel-
dc.contributor.authorCastro, Montserrat de-
dc.contributor.authorDėdelė, Audrius-
dc.contributor.authorDonaire-Gonzalez, David-
dc.contributor.authorEstivill, Xavier-
dc.contributor.authorEvandt, Jorunn-
dc.contributor.authorFossati, Serena-
dc.contributor.authorGiorgis-Allemand, Lise-
dc.contributor.authorGonzalez, Juan R-
dc.contributor.authorGranum, Berit-
dc.contributor.authorGražulevičienė, Regina-
dc.contributor.authorGützkow, Kristine Bjerve-
dc.contributor.authorHaug, Line Småstuen-
dc.contributor.authorHernandez-Ferrer, Carles-
dc.contributor.authorHeude, Barbara-
dc.contributor.authorIbarluzea, Jesus-
dc.contributor.authorJulvez, Jordi-
dc.contributor.authorKarachaliou, Marianna-
dc.contributor.authorKeun, Hector C-
dc.contributor.authorKrog, Norun Hjertager-
dc.contributor.authorLau, Chung-Ho E-
dc.contributor.authorLeventakou, Vasiliki-
dc.contributor.authorLyon-Caen, Sarah-
dc.contributor.authorManzano, Cyntia-
dc.contributor.authorMason, Dan-
dc.contributor.authorMcEachan, Rosemary R. C-
dc.contributor.authorMeltzer, Helle Margrete-
dc.contributor.authorPetravičienė, Inga-
dc.contributor.authorQuentin, Joane-
dc.contributor.authorRoumeliotaki, Theano-
dc.contributor.authorSabidó, Eduard-
dc.contributor.authorSaulnier, Pierre-Jean-
dc.contributor.authorSiskos, Alexandros P-
dc.contributor.authorSiroux, Valérie-
dc.contributor.authorSunyer, Jordi-
dc.contributor.authorTamayo-Uria, Ibon-
dc.contributor.authorUrquiza, Jose-
dc.contributor.authorVafeiadi, Marina-
dc.contributor.authorGent, Diana van-
dc.contributor.authorVives-Usano, Marta-
dc.contributor.authorWaiblinger, Dagmar-
dc.contributor.authorWarembourg, Charline-
dc.contributor.authorChatzi, Leda-
dc.contributor.authorCoen, Muireann-
dc.contributor.authorHazel, Peter Jan van den-
dc.contributor.authorNieuwenhuijsen, Mark J-
dc.contributor.authorSlama, Rémy-
dc.contributor.authorThomsen, Cathrine-
dc.contributor.authorWright, John-
dc.contributor.authorVrijheid, Martine-
dc.description.abstractPurpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations. Participants The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the UK). HELIX used a multilevel study design with the entire study population totalling 31 472 mother-child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6–11 years (second level) and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level). Findings to date Cohort data include urban environment, hazardous substances and lifestyle-related exposures for women during pregnancy and their offspring from birth until 6–11 years. Common, standardised protocols were used to collect biological samples, measure exposure biomarkers and omics signatures and assess child health across the six cohorts. Baseline data of the cohort show substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder. [...]en
dc.description.sponsorshipAplinkotyros katedra-
dc.description.sponsorshipGamtos mokslų fakultetas-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 1-17-
dc.relation.ispartofBMJ open [electronic resource]. London : BMJ Publishing Group Ltd, 2018, vol. 8, no. 9-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyCAB Abstracts-
dc.subjectChildren healthen
dc.subjectEarly life environmental exposuresen
dc.subject.otherEkologija ir aplinkotyra / Ecology and environmental sciences (N012)-
dc.titleHuman Early Life Exposome (HELIX) study: a European population-based exposome cohorten
dc.typeStraipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)-
dc.identifier.doi bmjopen-2017-021311-
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