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Type of publication: conference paper
Type of publication (PDB): Tezės Clarivate Analytics Web of Science / Theses in Clarivate Analytics Web of Science (T1a)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Žūkienė, Rasa;Šilkūnienė, Giedrė;Degutytė-Fomins, Laima;Naučienė, Zita;Mildažienė, Vida
Title: Hyperthermia : a systems approach in analysis of the effects on different organization levels
Is part of: Acta physiologica. New-York : Wiley-Blackwel, 2015, Vol. 215, suppl. 705
Extent: p. 49-49
Date: 2015
Note: FEPS 2015 : Joint meeting of the Federation of European Physiological Societies and the Baltic Physiological Societies in Kaunas, Lithuania, 26-29 August 2015 : abstracts. Kaunas : Baltic Physiological Societies, 2015. eISSN: 1748-1716, Acta physiologica
Keywords: Hipertermija;Sistemų požiūris;Organizacinis lygmuo;Hyperthermia;Systems approach;Organization levels
Abstract: Aim: Hyperthermia is a potent addendum to the existing cancer treatment modalities (surgery, chemotherapy and radiotherapy) that can improve clinical outcome up to 25%, however, the molecular and physiological mechanisms determining cellular fate during hyperthermia are still unclear. The present study is a systematic overview on effects of hyperthermic treatment on different organization levels (biomacromolecules, mitochondria, cells, liver tissue) considering cancer and normal tissues, different temperature ranges, gender, age, drugs and drug metabolites. Methods: Parameters evaluated under the conditions of hyperthermia (37-51ºC) in biomacromolecules: protein denaturation and lipid phase transition; in isolated mitochondria: mitochondrial respiratory rate in different metabolic states, mitochondrial swelling, membrane potential, ROS generation; in normal and cancer cell lines: cell viability, plasma and mitochondrial membrane permeability, Ca2+, adenine and pyridine nucleotides concentration; in liver perfusion and thermoablation experiments: NAD(P)H fluorescence, mitochondrial functions. The combined treatment of hyperthermia with cisplatin was evaluated in cell culture, with acetaminophen and its metabolite NAPQI in mitochondrial model. [...]
Affiliation(s): Aplinkotyros katedra
Biochemijos katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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