Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/44235
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dc.contributor.authorBustamante, Mariona-
dc.contributor.authorDanilevičiutė, Asta-
dc.contributor.authorEspinosa, Ana-
dc.contributor.authorGonzalez, Juan R-
dc.contributor.authorSubirana, I-
dc.contributor.authorCordier, Sylvaine-
dc.contributor.authorChevrier, Cecile-
dc.contributor.authorChatzi, Leda-
dc.contributor.authorGražulevičienė, Regina-
dc.contributor.authorSunyer, J-
dc.contributor.authorIbarluzea, J-
dc.contributor.authorBallester, Ferran-
dc.contributor.authorVillanueva, Cristina M-
dc.contributor.authorNieuwenhuijsen, Mark-
dc.contributor.authorEstivill, X-
dc.contributor.authorKogevinas, Manolis-
dc.coverage.spatialGB-
dc.date.accessioned2018-10-06T20:42:20Z-
dc.date.available2018-10-06T20:42:20Z-
dc.date.issued2012-
dc.identifier.issn14700328-
dc.identifier.otherVDU02-000012148-
dc.identifier.urihttps://hdl.handle.net/20.500.12259/44235-
dc.description.abstractA nested case–control association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.51–0.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.07–1.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manneren
dc.description.sponsorshipAplinkotyros katedra-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 1141–1146-
dc.language.isoen-
dc.relation.ispartofBJOG : an international journal of obstetrics and gynaecology. Oxford : Blackwell Science, 2012, vol. 119, iss. 9-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyScopus-
dc.subjectCopy number varianten
dc.subjectGlutathione S-transferaseen
dc.subjectPretermen
dc.subjectGestational ageen
dc.subject.classificationStraipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)-
dc.subject.otherEkologija ir aplinkotyra / Ecology and environmental sciences (N012)-
dc.titleInfluence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomesen
dc.typeresearch article-
dc.identifier.doihttps://doi.org/10.1111/j.1471-0528.2012.03400.x-
dc.identifier.isiWOS:000306221000015-
dcterms.bibliographicCitation6-
dc.date.updated2020-02-06T16:05Z-
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item.grantfulltextopen-
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crisitem.author.deptAplinkotyros katedra-
crisitem.author.deptAplinkotyros katedra-
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications
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