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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Ekologija ir aplinkotyra / Ecology and environmental sciences (N012)
Author(s): Bustamante, Mariona;Danilevičiutė, Asta;Espinosa, Ana;Gonzalez, Juan R;Subirana, I;Cordier, Sylvaine;Chevrier, Cecile;Chatzi, Leda;Gražulevičienė, Regina;Sunyer, J;Ibarluzea, J;Ballester, Ferran;Villanueva, Cristina M;Nieuwenhuijsen, Mark;Estivill, X;Kogevinas, Manolis
Title: Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes
Is part of: BJOG : an international journal of obstetrics and gynaecology. Oxford : Blackwell Science, 2012, vol. 119, iss. 9
Extent: p. 1141–1146
Date: 2012
Keywords: Copy number variant;Glutathione S-transferase;Preterm;Gestational age
Abstract: A nested case–control association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.51–0.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.07–1.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner
Affiliation(s): Aplinkotyros katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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