Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/112029
Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Ekologija ir aplinkotyra / Ecology and environmental sciences (N012)
Author(s): Granum, Berit;Oftedal, Bente;Agier, Lydiane;Siroux, Valérie;Bird, Philippa K;Casas, Maribel;Warembourg, Charline;Wright, John;Chatzi, Leda;Castro, Montserrat de;Donaire, David;Gražulevičienė, Regina;Haug, Line Småstuen;Maitre, Lea;Robinson, Oliver;Tamayo-Uria, Ibon;Urquiza, Jose;Nieuwenhuijsen, Mark;Slama, Rémy;Thomsen, Cathrine;Vrijheid, Martine
Title: Multiple environmental exposures in early-life and allergy-related outcomes in childhood
Is part of: Environment international. Amsterdam : Elsevier B.V., 2020, vol. 144
Extent: p. 1-16
Date: 2020
Note: Article Number: 106038
Keywords: Childhood;Exposome;Environmental exposure;Allergic disease;Pregnancy
Abstract: Introduction: Early onset and high prevalence of allergic diseases result in high individual and socio-economic burdens. Several studies provide evidence for possible effects of environmental factors on allergic diseases, but these are mainly single-exposure studies. The exposome provides a novel holistic approach by simultaneously studying a large set of exposures. The aim of the study was to evaluate the association between a broad range of prenatal and childhood environmental exposures and allergy-related outcomes in children. Material and Methods: Analyses of associations between 90 prenatal and 107 childhood exposures and allergy-related outcomes (last 12 months: rhinitis and itchy rash; ever: doctor-diagnosed eczema and food allergy) in 6-11 years old children (n = 1270) from the European Human Early-Life Exposome cohort were performed. Initially, we used an exposome-wide association study (ExWAS) considering the exposures independently, followed by a deletion-substitution-addition selection (DSA) algorithm considering all exposures simultaneously. All the exposure variables selected in the DSA were included in a final multi-exposure model using binomial general linear model (GLM). Results: In ExWAS, no exposures were associated with the outcomes after correction for multiple comparison. In multi-exposure models for prenatal exposures, lower distance of residence to nearest road and higher di-isononyl phthalate level were associated with increased risk of rhinitis, and particulate matter absorbance (PMabs) was associated with a decreased risk. Furthermore, traffic density on nearest road was associated with increased risk of itchy rash and diethyl phthalate with a reduced risk. DSA selected no associations of childhood exposures, or between prenatal exposures and eczema or food allergy
Internet: https://doi.org/ 10.1016/j.envint.2020.106038
Affiliation(s): Aplinkotyros katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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