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Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Ekologija ir aplinkotyra / Ecology and environmental sciences (N012)
Author(s): Vives-Usano, Martha;Hernandez-Ferrer, Carles;Maitre, Léa;Ruiz-Arenas, Carlos;Andrušaitytė, Sandra;Borràs, Eva;Carracedo, Angel;Casas, Maribel;Chatzi, Leda;Coen, Muireann;Estivill, Xavier;Gonzalez, Juan R;Gražulevičienė, Regina;Gutzkow, Kristine B;Keun, Hector C;Lau, Chung-Ho E;Cadiou, Solène;Lepeule, Johanna;Mason, Dan;Quintela, Inés;Robinson, Oliver;Sabidó, Eduardo;Santorelli, Gillian;Schwarze, Per E;Siskos, Alexandros P;Slama, Rémy;Vafeiadi, Marina;Martí, Eulàlia;Vrijheid, Martine;Bustamante, Mariona
Title: In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children
Is part of: BMC medicine. London : Springer Nature, 2020, vol. 18, iss. 1
Extent: p. 1-43
Date: 2020
Note: Article number: 243
Keywords: Tobacco smoking;Secondhand smoke;Children;Pregnancy;Omics;Molecular phenotypes;DNA methylation;miRNA;Metabolomics
Abstract: Background The adverse health effects of early life exposure to tobacco smoking have been widely reported. In spite of this, the underlying molecular mechanisms of in utero and postnatal exposure to tobacco smoke are only partially understood. Here, we aimed to identify multi-layer molecular signatures associated with exposure to tobacco smoke in these two exposure windows. Methods We investigated the associations of maternal smoking during pregnancy and childhood secondhand smoke (SHS) exposure with molecular features measured in 1203 European children (mean age 8.1 years) from the Human Early Life Exposome (HELIX) project. Molecular features, covering 4 layers, included blood DNA methylation and gene and miRNA transcription, plasma proteins, and sera and urinary metabolites. Results Maternal smoking during pregnancy was associated with DNA methylation changes at 18 loci in child blood. DNA methylation at 5 of these loci was related to expression of the nearby genes. However, the expression of these genes themselves was only weakly associated with maternal smoking. Conversely, childhood SHS was not associated with blood DNA methylation or transcription patterns, but with reduced levels of several serum metabolites and with increased plasma PAI1 (plasminogen activator inhibitor-1), a protein that inhibits fibrinolysis. Some of the in utero and childhood smoking-related molecular marks showed dose-response trends, with stronger effects with higher dose or longer duration of the exposure. Conclusion In this first study covering multi-layer molecular features, pregnancy and childhood exposure to tobacco smoke were associated with distinct molecular phenotypes in children. The persistent and dose-dependent changes in the methylome make CpGs good candidates to develop biomarkers of past exposure. [...]
Affiliation(s): Aplinkotyros katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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