Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/106150
Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Ekologija ir aplinkotyra / Ecology and environmental sciences (N012)
Author(s): Evlampidou, Iro;Font-Ribera, Laia;Rojas-Rueda, David;Gracia-Lavedan, Esther;Costet, Nathalie;Peasey, Anne;Vineis, Paolo;Jaakkola, Jouni J.K;Delloye, Francis;Makris, Konstantinos C;Stephanou, Euripides G;Kargaki, Sophia;Kozisek, Frantisek;Sigsgaard, Torben;Hansen, Birgitte;Schullehner, Jörg;Nahkur, Ramon;Galey, Catherine;Zwiener, Christian;Vargha, Marta;Righi, Elena;Aggazzotti, Gabriella;Kalnina, Gunda;Gražulevičienė, Regina;Polanska, Kinga;Gubkova, Dasa;Bitenc, Katarina;Goslan, Emma H;Kogevinas, Manolis;Villanueva, Cristina M
Title: Trihalomethanes in drinking water and bladder cancer burden in the European Union
Is part of: Environmental health perspectives. Research Triangle Park, USA : National Institute of Environmental Health Sciences, 2020, vol. 128, iss. 1
Extent: p. 1-14
Date: 2020
Keywords: Trihalometanai;Geriamasis vanduo;Vėžys
Abstract: BACKGROUND: Trihalomethanes (THMs) are widespread disinfection by-products (DBPs) in drinking water, and long-term exposure has been consistently associated with increased bladder cancer risk. OBJECTIVE: We assessed THM levels in drinking water in the European Union as a marker of DBP exposure and estimated the attributable burden of bladder cancer. METHODS: We collected recent annual mean THM levels in municipal drinking water in 28 European countries (EU28) from routine monitoring records. We estimated a linear exposure–response function for average residential THM levels and bladder cancer by pooling data from studies included in the largest international pooled analysis published to date in order to estimate odds ratios (ORs) for bladder cancer associated with the mean THM level in each country (relative to no exposure), population-attributable fraction (PAF), and number of attributable bladder cancer cases in different scenarios using incidence rates and population from the Global Burden of Disease study of 2016. RESULTS: We obtained 2005–2018 THM data from EU26, covering 75% of the population. Data coverage and accuracy were heterogeneous among countries. The estimated population-weighted mean THM level was 11:7 lg=L [standard deviation (SD) of 11.2]. The estimated bladder cancer PAF was 4.9% [95% confidence interval (CI): 2.5, 7.1] overall (range: 0–23%), accounting for 6,561 (95% CI: 3,389, 9,537) bladder cancer cases per year. Denmark and the Netherlands had the lowest PAF (0.0% each), while Cyprus (23.2%), Malta (17.9%), and Ireland (17.2%) had the highest among EU26. In the scenario where no country would exceed the current EU mean, 2,868 (95% CI: 1,522, 4,060; 43%) annual attributable bladder cancer cases could potentially be [...]
Internet: https://doi.org/10.1289/EHP4495
Affiliation(s): Aplinkotyros katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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