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dc.contributor.authorWarembourg, Charline-
dc.contributor.authorMaitre, Léa-
dc.contributor.authorTamayo-Uria, Ibon-
dc.contributor.authorFossati, Serena-
dc.contributor.authorRoumeliotaki, Theano-
dc.contributor.authorAasvang, Gunn Marit-
dc.contributor.authorAndrušaitytė, Sandra-
dc.contributor.authorCasas, Maribel-
dc.contributor.authorCequier, Enrique-
dc.contributor.authorChatzi, Leda-
dc.contributor.authorDėdelė, Audrius-
dc.contributor.authorGonzalez, Juan R-
dc.contributor.authorGražulevičienė, Regina-
dc.contributor.authorHaug, Line Småstuen-
dc.contributor.authorHernandez-Ferrer, Carles-
dc.contributor.authorHeude, Barbara-
dc.contributor.authorKarachaliou, Marianna-
dc.contributor.authorKrog, Norun Hjertager-
dc.contributor.authorMcEachan, Rosemary R. C-
dc.contributor.authorNieuwenhuijsen, Mark-
dc.contributor.authorPetravičienė, Inga-
dc.contributor.authorQuentin, Joane-
dc.contributor.authorRobinson, Oliver-
dc.contributor.authorSakhi, Amrit K-
dc.contributor.authorSlama, Rémy-
dc.contributor.authorThomsen, Cathrine-
dc.contributor.authorUrquiza, Jose-
dc.contributor.authorVafeiadi, Marina-
dc.contributor.authorWest, Jane-
dc.contributor.authorWright, John-
dc.contributor.authorVrijheid, Martine-
dc.contributor.authorBasagaña, Xavier-
dc.description.abstractBackground. Growing evidence exists about the fetal and environmental origins of hypertension, but mainly limited to single-exposure studies. The exposome has been proposed as a more holistic approach by studying many exposures simultaneously. Objectives. This study aims to evaluate the association between a wide range of prenatal and postnatal exposures and blood pressure (BP) in children. Methods. Systolic and diastolic BP were measured among 1,277 children from the European HELIX (Human Early-Life Exposome) cohort aged 6 to 11 years. Prenatal (n = 89) and postnatal (n = 128) exposures include air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals, and lifestyles. Two methods adjusted for confounders were applied: an exposome-wide association study considering the exposures independently, and the deletion-substitution-addition algorithm considering all the exposures simultaneously. Results. Decreases in systolic BP were observed with facility density (β change for an interquartile-range increase in exposure: −1.7 mm Hg [95% confidence interval (CI): −2.5 to −0.8 mm Hg]), maternal concentrations of polychlorinated biphenyl 118 (−1.4 mm Hg [95% CI: −2.6 to −0.2 mm Hg]) and child concentrations of dichlorodiphenyldichloroethylene (DDE: −1.6 mm Hg [95% CI: −2.4 to −0.7 mm Hg]), hexachlorobenzene (−1.5 mm Hg [95% CI: −2.4 to −0.6 mm Hg]), and mono−benzyl phthalate (−0.7 mm Hg [95% CI: −1.3 to −0.1 mm Hg]), whereas increases in systolic BP were observed with outdoor temperature during pregnancy (1.6 mm Hg [95% CI: 0.2 to 2.9 mm Hg]), high fish intake during pregnancy (2.0 mm Hg [95% CI: 0.4 to 3.5 mm Hg]), maternal cotinine concentrations (1.2 mm Hg [95% CI: -0.3 to 2.8 mm Hg]), and child perfluorooctanoate concentrations (0.9 mm Hg [95% CI: 0.1 to 1.6 mm Hg]). [...]en
dc.description.sponsorshipAplinkotyros katedra-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 1317-1328-
dc.relation.ispartofJournal of the American College of Cardiology. New York: Elsevier Science, 2019, Vol. 74, iss. 10-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyAcademic Search Premier (EBSCO)-
dc.subjectKraujo spaudimaslt
dc.subjectBlood pressureen
dc.subject.classificationStraipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)-
dc.subject.otherEkologija ir aplinkotyra / Ecology and environmental sciences (N012)-
dc.titleEarly-life environmental exposures and blood pressure in childrenen
dc.typeresearch article-
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