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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Ekologija ir aplinkotyra / Ecology and environmental sciences (N012)
Author(s): Clemente, Diana B. P;Vrijheid, Martine;Martens, Dries S;Bustamante, Mariona;Chatzi, Leda;Danilevičiutė, Asta;Castro, Montserrat de;Gražulevičienė, Regina;Gutzkow, Kristine B;Lepeule, Johanna;Maitre, Léa;McEachan, Rosie R.C;Robinson, Oliver;Schwarze, Per E;Tamayo, Ibon;Vafeiadi, Marina;Wright, John;Slama, Rémy;Nieuwenhuijsen, Mark;Nawrot, Tim S
Title: Prenatal and childhood traffic-related air pollution exposure and telomere length in European children: the HELIX project
Is part of: Environmental health perspectives. Research Triangle Park, USA : National Institute of Environmental Health Sciences, 2019, Vol. 127, iss. 8
Extent: p. 1-8
Date: 2019
Note: article no. 087001
Keywords: Pregnancy;Risk;Health
Abstract: BACKGROUND: Telomere length is a molecular marker of biological aging. OBJECTIVE: Here we investigated whether early-life exposure to residential air pollution was associated with leukocyte telomere length (LTL) at 8 y of age. METHODS: In a multicenter European birth cohort study, HELIX (Human Early Life Exposome) (n= 1,396), we estimated prenatal and 1-y childhood exposure to nitrogen dioxide (NO2), particulate matter with aerodynamic diameter ≤2:5 lm (PM2:5), and proximity to major roads. Average relative LTL was measured using quantitative real-time polymerase chain reaction (qPCR). Effect estimates of the association between LTL and prenatal, 1-y childhood air pollution, and proximity to major roads were calculated using multiple linear mixed models with a random cohort effect and adjusted for relevant covariates. RESULTS: LTL was inversely associated with prenatal and 1-y childhood NO2 and PM2:5 exposures levels. Each standard deviation (SD) increase in prenatal NO2 was associated with a −1:5% (95% CI: −2:8, −0:2) change in LTL. Prenatal PM2:5 was nonsignificantly associated with LTL (−0:7% per SD increase; 95% CI: −2:0, 0.6). For each SD increment in 1-y childhood NO2 and PM2:5 exposure, LTL shortened by −1:6% (95% CI: −2:9, −0:4) and −1:4% (95% CI: −2:9, 0.1), respectively. Each doubling in residential distance to nearest major road during childhood was associated with a 1.6% (95% CI: 0.02, 3.1) lengthening in LTL. CONCLUSION: Lower exposures to air pollution during pregnancy and childhood were associated with longer telomeres in European children at 8 y of age. These results suggest that reductions in traffic-related air pollution may promote molecular longevity, as exemplified by telomere length, from early life onward
Affiliation(s): Aplinkotyros katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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