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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Chemija / Chemistry (N003)
Author(s): Gefenas, Vladas;Stankevičiūtė, Ž;Malinauskas, Albertas
Title: N(1)-, N(3)-, and O-alkylation of 5-cyano- 2-methylsulfanyl-4(3h)-pyrimidinone by 4-substituted ω-Bromoacetophenones in the system acetonitrile-K2CO3
Is part of: Chemistry of heterocyclic compounds. , Vol. 45, iss. 11 (2009)
Extent: p. 1413-1415
Date: 2009
Keywords: ω-Bromoacetophenones;Potassium carbonate;5-cyano-2-methylsulfanyl-4(3H)-pyrimidi-none;N(1)-;N(3)-;O-alkylation;Acetonitrile
Abstract: Alkylation of 4(3H)-pyrimidinones occurs to give a mixture of N(1)-, N(3)-, and O-alkylation products [1]. Analysis of literature data shows that alkylation with haloacetic esters, chloroacetonitrile, N-benzyl-haloacylamides, 3-bromopropan-1-ol, or ω-bromoacetophenone generally gives just the O- and N(3)-alkylation products. According to our results N(1)-alkylation products have hardly been studied and only discovered and separated with the use of haloalkanes and benzyl halides as alkylating agent [1-4]
Affiliation(s): Chemijos institutas
Vytauto Didžiojo universitetas
Švietimo akademija
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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