Plasmonic nanoprobes for surface enhanced raman spectroscopy of biological molecules

Abstract

Our intent in this presentation is to discuss the basics of SERS and summarize its applications in biomedical sciences. Specifically, we will introduce the physical and chemical concepts relevant to the approaches to achieve single molecule SERS. The specific case of SERS, a tipenhanced Raman and application for proteins interaction with nanoparticles research will be discussed. In this work we demonstrate the preparation of ordered silver nano-wedges array based SERS substrates, fabricated by chemical reduction of silver ions on hydrofluoric acid etched silicon wafers. The theoretical model of electromagnetic field distribution on the substrate surface was performed using COMSOL software. The enhancement effect of Raman scattering for single molecule was tested by evaporating monolayer of pentacene (2 nm) on bare silicon wafer and SERS substrate