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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Veterinarija / Veterinary (A002)
Author(s): Cicėnas, Jonas;Kvederavičiūtė, Kotryna;Meškinytė, Ingrida;Meškinytė-Kaušilienė, Edita;Skeberdytė, Aistė;Cicėnas, Jonas
Title: KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer
Is part of: Cancers. Basel : MDPI AG, 2017, vol. 9, iss. 5
Extent: p. 1-9
Date: 2017
Keywords: KRAS;TP53;CDKN2A;SMAD4;BRCA1;BRCA2;Mutation;Pancreatic cancer;Genetic variant
Abstract: Pancreatic cancer is a disease that has a very high fatality rate and one of the highest mortality ratios among all major cancers, remaining the fourth leading cause of cancer-related deaths in developed countries. The major treatment of pancreatic cancer is surgery; however, only 15–20% of patients are candidates for it at the diagnosis of disease. On the other hand, survival in patients, who undergo surgery, is less than 30%. In most cancers, genome stability is disturbed and pancreatic cancer is not the exception. Approximately 97% of pancreatic cancers have gene derangements, defined by point mutations, amplifications, deletions, translocations, and inversions. This review describes the most frequent genetic alterations found in pancreatic cancer
Affiliation(s): Lietuvos Respublikos švietimo ir mokslo ministerija
Tarptautinė teisės ir verslo aukštoji mokykla
University of Bern, Switzerland
Vilniaus universitetas
Vytauto Didžiojo universitetas
Žemės ūkio akademija
Appears in Collections:1. Straipsniai / Articles
Universiteto mokslo publikacijos / University Research Publications

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