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Type of publication: conference paper
Type of publication (PDB): Konferencijų tezės nerecenzuojamuose leidiniuose / Conference theses in non-peer-reviewed publications (T2)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Radzevičiūtė, Eivina;Januškevičienė, I;Daugelavičius, Rimantas
Title: Antioxidants effect on MX-1 cells resistance
Is part of: Smart Bio : ICSB 2nd international conference, 3-5 May 2018, Kaunas : abstracts book. Kaunas : Vytautas Magnus University, 2018
Extent: p. 85-85
Date: 2018
Keywords: Cancer;Multidrug resistance;Rutin;Epigallocatechin gallate
ISBN: 9786098104486
Abstract: Background. Multidrug resistance (MDR) is simultaneous resistance of cancer cells to many drugs used for chemotherapy. The main mechanism of MDR is multidrug resistance efflux pumps. It is a large superfamily of proteins called the ATP-binding cassette (ABC) transporters. The main efflux pumps responsible for MDR are P-glycoprotein (P-gp), multidrug-resistance protein (MRP) and breast cancer resistance protein (BCRP) (1). In this study we explored antioxidants inhibition activity to efflux pump. The aim: to investigate the effects of antioxidants on breast cancer cell line. Methods. The levels of MX-1 cell resistance to rutin (R), quercetin (Q) and epigallocatechin gallate (EGCG) were estimated using MTT viability test. The MDR pump functional activity was determined by fluorometric measurements. Results. In this study was derived a new MX-1 cells sublines resistance to rutin, quercetin and epigallocatechin gallate. These cells sublines showed different functional activity of the MDR pumps. Conclusion. All antioxidants on MX-1 cells affected differently. Quercetin increased the functional activity of the pumps, while epigallocatechin gallate suppressed
Affiliation(s): Biochemijos katedra
Gamtos mokslų fakultetas
Lietuvos sveikatos mokslų universitetas. Medicinos akademija
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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