Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/60399
Type of publication: Straipsnis Clarivate Analytics Web of Science Master Journal List / Article in Clarivate Analytics Web of Science Master Journal List (S2)
Field of Science: Biologija / Biology (N010)
Author(s): Karaliūtė, Rasa;Gustienė, Olivija;Kupstytė, Nora;Ambrasienė, Daiva;Tatarūnas, Vacis
Title: Bedside stratification of patients according to CYP2C19*2 genotype
Other Title: Išemine širdies liga sergančių pacientų identifikavimas pagal CYP2C19*2 genotipą
Is part of: Biologija = Biology. Vilnius : Lietuvos mokslų akademijos leidykla, 2018, vol. 64, nr. 2
Extent: p. 166-171
Date: 2018
Keywords: Stento trombozė;CYP2C19 variantas;Klopidogrelis;Antiagregantai;Stent thrombosis;CYP2C19;Clopidogrel;Antiplatelets
Abstract: Išemine širdies liga sergantiems pacientams, ku-riems išsivysto stento trombozė arba gydant anti-agregantais nustatomas didelis trombocitų reakty-vumas, siekėme nustatyti patologinį CYP2C19*2 alelį, taikydami naują greitai genotipą nustatantį metodą. Iš viso tyrime dalyvavo 35 pacientai. Visi pacientai buvo ištirti dėl CYP2C19*2 naudojant Spartan RX CYP2C19 tyrimų paketą. CYP2C19*1*1 genetinis variantas nustatytas 63 %, *1*2 – 34 %, *2*2 – 2 % tirtų pacientų. Vyrų ir moterų grupėse skirtingi genotipai pasiskirstė panašiai. CYP2C19*2 alelį, lemiantį blogesnį klopidogrelio antitromboci-tinį efektą, greitu genotipo identifikacijos metodu galima nustatyti greičiau nei per valandą
Objective. The task was to identify the defective CYP2C19*2 allele by using a novel fast-genotyping method in the patients having coronary artery disease who developed stent thrombosis or high on-treatment platelet reactivity. Materials and methods. A total of 35 patients were included in the study. All the patients were screened for CYP2C19*2 using Spartan RX CYP2C19 Assay Package. Results. CYP2C19*1*1 variant was found in 63%, *1*2 in 34%, *2*2 in 3% of patients. The distribution of genotypes was similar in men and women. Conclusions. By using the bedside technique, CYP2C19*2, which is responsible for a poorer effect of clopidogrel, might be identified in less than an hour
Internet: https://doi.org/10.6001/biologija.v64i2.3740
https://www.lmaleidykla.lt/ojs/index.php/biologija/article/view/3740/2538
Affiliation(s): Biologijos katedra
Lietuvos sveikatos mokslų universitetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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