Use this url to cite publication: https://hdl.handle.net/20.500.12259/60171
Enhancement of drug electrotransfer by extracellular plasmid DNA
Type of publication
Straipsnis Web of Science ir Scopus duomenų bazėje / Article in Web of Science and Scopus database (S1)
Author(s)
Author | Affiliation | |
---|---|---|
LT | ||
LT | ||
LT | ||
LT |
Title [en]
Enhancement of drug electrotransfer by extracellular plasmid DNA
Is part of
Archives of biochemistry and biophysics
Date Issued
Date | Volume |
---|---|
2019 | 666 |
Publisher
New York : Elsevier inc
Publisher (trusted)
Extent
p. 156-160
Abstract (en)
Electroporation is a widely established method for molecular delivery across electric field perturbed plasma membrane. It can be used as a non-viral DNA transfection method, or as a way to achieve small molecule delivery to or extraction from cells. We examined the possibility of combining the DNA delivery to the cells with small molecule transport across electroporated plasma membrane. The results show that the presence of DNA in electroporation medium increases the extraction of fluorescent dye calcein from calcein-AM loaded cells as well as the delivery of small-molecule drug bleomycin to the cells. We propose that these results may have implications in enhanced drug delivery using electroporation both in vivo and in clinics.
Type of document
type::text::journal::journal article::research article
Language
Anglų / English (en)
Coverage Spatial
Jungtinės Amerikos Valstijos / United States of America (US)
File(s)23316.pdf (561.88 KB) Closed Access
ISSN (of the container)
0003-9861
WOS
WOS:000469894900018
Other Identifier(s)
VDU02-000023316
Funding(s)
Research Council of Lithuania
Access Rights
Nėra prieigos / Closed Access
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 3.391 | 4.178 | 3.663 | 4.694 | 2 | 0.762 | 2019 | Q2 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 3.391 | 4.178 | 3.663 | 4.694 | 2 | 0.762 | 2019 | Q2 |
Journal | Cite Score | SNIP | SJR | Year | Quartile |
---|---|---|---|---|---|
Archives of Biochemistry and Biophysics | 6.3 | 1.046 | 1.081 | 2019 | Q1 |