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Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Biofizika / Biophysics (N011);Fizika / Physics (N002)
Author(s): Ruzgys, Paulius;Jakutavičiūtė, Milda;Chopra, Sonam;Šatkauskas, Saulius
Title: Enhancement of drug electrotransfer by extracellular plasmid DNA
Is part of: Archives of biochemistry and biophysics. New York : Elsevier inc., 2019, vol. 666
Extent: p. 156-160
Date: 2019
Note: This work was supported by the grant (DOTSUT–09.3.3-LMT-K-712- 01-0188) from the Research Council of Lithuania
Keywords: Drug delivery;Electroporation;Bleomycin;Calcein;DNA electrotransfer;Plasmid DNA
Abstract: Electroporation is a widely established method for molecular delivery across electric field perturbed plasma membrane. It can be used as a non-viral DNA transfection method, or as a way to achieve small molecule delivery to or extraction from cells. We examined the possibility of combining the DNA delivery to the cells with small molecule transport across electroporated plasma membrane. The results show that the presence of DNA in electroporation medium increases the extraction of fluorescent dye calcein from calcein-AM loaded cells as well as the delivery of small-molecule drug bleomycin to the cells. We propose that these results may have implications in enhanced drug delivery using electroporation both in vivo and in clinics
Affiliation(s): Aplinkos tyrimų centras
Biologijos katedra
Gamtos mokslų fakultetas
Vytauto Didžiojo universitetas
Appears in Collections:1. Straipsniai / Articles
Universiteto mokslo publikacijos / University Research Publications

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