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Type of publication: Straipsnis konferencijos medžiagoje Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or Scopus DB conference proceedings (P1a)
Field of Science: Biologija / Biology (N010)
Author(s): Didvalis, Tadas;Ruzgys, Paulius;Šatkauskas, Saulius;Adlienė, Diana;Mickevičius, Saulius
Title: Cell viability, DNA damage and relative mitotic arrest dependence on radiation dose
Is part of: Medical physics in the Baltic states : proceedings of the 13th international conference on medical physics, Kaunas, Lithuania, 9-11 November, 2017. Kaunas : Kaunas University of Technology, 2017, 13
Extent: p. 41-44
Date: 2017
Keywords: DNA damage;Cells;X-ray beam;Comet assay
Abstract: Research on in vitro X-ray irradiated cell behavior contributes significantly to the enhancement of radiotherapy treatment efficacy in clinics. The results of investigation performed with Chinese hamster ovary (CHO) cells irradiated in linear accelerator Varian Clinac DMX (X-rays, 6 MeV and 3 Gy/min) to different doses from the interval 2 - 10 Gy are presented in this paper. Irradiated cells were analyzed using COMET assay within two hours after treatment and DNA damages in cells were assessed. Also clonogenic assay was performed to determine cell viability and formed cell colony area dependence on irradiated dose. Direct dependency of cell viability, DNA damage and relative cell division capability on irradiation dose was found. It was also found that cell division arrest plateau phase starts from 6 Gy. Obtained results are discussed in the frame of radiation induced effects in irradiated cells
Affiliation(s): Biologijos katedra
Fizikos katedra
Gamtos mokslų fakultetas
Kauno technologijos universitetas
Lietuvos sveikatos mokslų universitetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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