Hemagglutinin fraction from Echinacea purpurea L. (Moench) roots impact on mice kidney morphology / Gabriele Balciunaite, Danas Baniulis, Ona Ragazinskiene, Vytautas Baranauskas, Ramune Grigaleviciute, Vilma Zigmantaite, Nomeda Juodziukyniene, Dalia Pangonytė, Nijole Savickiene

Abstract

Introduction. Lecitins or hemagglutinins are non-immune origin glycoproteins, which can bind carbohydrate structures in specific and reversible manner. They have big potential for their therapeutical applications such as immunomodulatory, anticancer, antibacterial and other activities. Hemagglutinins from Echinacea purpurea L. (Moench) roots haven't been investigated and tested on animal models in vivo. Aim. To purify hemagglutinins from Echinacea purpurea L. (Moench) roots and test their activity on mice kidney morphology in vivo. Material and methods. 1. Affinity column with immobilized D-(+)-mannose ligands was equilibrated with phosphate buffer saline (PBS) pH 7,4. [...]