Phenolic metabolites and antimicrobial activity of Angelica Archangelica L

Abstract

Angelica archangelica L. is an important medicinal herb used in medicine of the Far East and certain Western countries. This plant accumulates phenolic compounds that are involved in many metabolic processes and are considered as biologically active. Additionally phenolic compounds possess antimicrobial activity and Angelica archangelica L. is classified as antimicrobial plant. The aim of this work was to investigate chemical composition of Angelica archangelica L. and evaluate antimicrobial activity. Angelica archangelica L. was grown in the section of medicinal plants of botanical garden Vytautas Magnus University. The plant was taken during the period of massive blooming and dried. Dried material was grinded and extracted using 75 % methanol – water mixture with the ratio of 1: 20. The extracts were filtered an analyzed using high performance liquid chromatography with radical scavengin reaction detection of DPPH. Antimicrobial activity was tested against following bacteria: Escherichia coli, Proteus vulgaris and Staphylococcus aureus with and without antibiotic resistances originating from livestock. In Angelica archangelica L. was identified following compounds: imperatorin, oxypeucedanin, byakangelicol, phellopterin provided highest radical scavenging activity. The extract of Angelica archangelica L. was found to be active against following bacteria: Escherichia coli, Proteus vulgaris and Staphylococcus aureus. Angelica archangelica L. contains high quantity of biologically active compounds and provide antimicrobial activity against certain bacteria. This study was supported by a postdoctoral research fellowship. Postdoctoral fellowship is being funded by European Union Structural Funds project ―Postdoctoral Fellowship Implementation in Lithuania