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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Farmacija / Pharmacy (M003)
Author(s): Pudžiuvelytė, Lauryna;Stankevičius, Mantas;Maruška, Audrius Sigitas;Petrikaitė, Vilma;Ragažinskienė, Ona;Drakšienė, Gailutė;Bernatonienė, Jurga
Title: Chemical composition and anticancer activity of Elsholtzia ciliata essential oils and extracts prepared by different methods
Is part of: Industrial crops and products. Amsterdam : Elsevier, 2017, vol. 107
Extent: p. 90-96
Date: 2017
Note: WOS:000412963900012
Keywords: Elsholtzia ciliata;Anticancer activity;Essential oil;Ethanolic extracts;Hydrodistillation;GC–MS
Abstract: E. ciliata (Lamiaceae) is very interesting and promising herb mainly for chemical composition and pharmacological activities. The aim of this study was to determine chemical composition of the essential oils of fresh, frozen and dried herbal materials of E. ciliata and compare different extraction methods This is the first study on composition of E. ciliata volatile compounds from fresh, frozen and dried herbal samples. The samples were prepared by hydrodistillation (HD), extraction with polar solvent-ethanol (ESE) and dynamic headspace solidphase micro extraction (SPME) and analyzed by gas chromatography-mass spectrometry (GC–MS) method. A total of 48 compounds were identified by GC–MS. Dehydroelsholtzia ketone, elsholtzia ketone, sesquiterpenes β- bourbonene, caryophyllene, α-caryophyllene, germacrene D and α-farnesene were identified and found to be predominant compounds in SPME composition of the fresh, frozen and dried herbal samples. The major amounts of ketones (dehydroelsholtzia and elsholtzia) were determined in dried herbal samples where they made up 24.94% (p < 0.05) and 71.34% (p < 0.05) of the SPME composition. Artemisia ketone was determined only in fresh herb. No previous report exists regarding this ketone in E. ciliata fresh, frozen and dried herbal materials or essential oil. There were 26 components identified in the essential oil obtained by HD. The main compounds of this essential oil were dehydroelsholtzia ketone (78.28%) and elsholtzia ketone (14.58%). Essential oil showed antiproliferative activity on three tested cancer cell lines (human glioblastoma (U87), pancreatic cancer (Panc-1) and triple negative breast cancer (MDA-MB231)) in vitro. EC50 (half maximal effective concentration) values of essential oil against those cells were in the range of 0.017–0.021%. [...]
Affiliation(s): Botanikos sodas
Instrumentinės analizės APC
Lietuvos sveikatos mokslų universitetas. Medicinos akademija
Vilniaus universitetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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