Contactless conductivity detection: development and application in pharmaceutical and related sciences

Abstract

Contactless conductivity detection is one of the most robust and cost effective technologies that can be coupled to capillary electrophoresis, ion, normal phase and HILIC chromatography in quality control of pharmaceuticals and research. During past decade the detector has been miniaturized to the scale of a coin making it easy to integrate the instrument into portable, or rare maintenance requiring instrumentation. The detector is capable of sensing charged molecules, or analytes that alter conductivity of the electrolyte, or media. The literature reports, that contactless conductivity detection can determine inorganic cations and anions and organic ions such as phenolic acids, phenols, amino acids, amines, proteins, oligopeptides, alkaloids and sugars. In this presentation issues designing and optimizing the instrument, developed and in literature reported applications will be reviewed.