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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Farmacija / Pharmacy (M003);Biochemija / Biochemistry (N004);Chemijos inžinerija / Chemical engineering (T005)
Author(s): Maruška, Audrius;Ugenskienė, Rasa;Raulinaitytė, Danguolė;Juozaitytė, Elona;Kaškonienė, Vilma;Drevinskas, Tomas;Stelmakienė, Ada;Akuneca, Ieva;Makaravičius, Tomas;Tiso, Nicola;Bartkuvienė, Violeta;Kornyšova, Olga;Ragažinskienė, Ona;Ramanauskienė, Kristina;Briedis, Vitalis
Title: Analysis of antiproliferative effect of Chamerion angustifolium water extract and its fractions on several breast cancer cell lines
Is part of: Advances in medical sciences. Amsterdam : Elsevier, 2017, vol. 62, no. 1
Extent: p. 158-164
Date: 2017
Note: Original research article ; authors (15) ; the Study was financially supported by the Research Council of Lithuania (grant no. MIP 084/2012 ONKOFITAS)
Keywords: Breast neoplasms;drug therapy;Breast neoplasms;cytology;MCF7 cells;drug effects;Antineoplastic agents, phytogenic;pharmacology;Onagraceae;chemistry;Plant extracts;pharmacology
Abstract: PURPOSE: To evaluate the antiproliferative effect of the aerial part of Chamerion angustifolium (L.) Holub. (Onagraceae) extract and its fractions in vitro. This is the first study on the anti-proliferative effect of C. angustifolium on 3 distinct breast cancer cell lines. MATERIAL/METHODS: Breast cancer cell lines MCF7, MDA-MB-468 and MDA-MB-231 were exposed to different concentrations of the water extract of C. angustifolium, where DPPH radical scavenging activity was 0.018-0.443mg/ml, expressed in rutin equivalents. Cell growth was analyzed after 24, 48 and 72h of incubation. Solid-phase extraction was applied for the fractionation of C. angustifolium water extract and MDA-MB-468 cell line growth was tested using different fractions. RESULTS: The concentrations corresponding to radical scavenging activity of 0.117 and 0.266mg/ml caused MCF7 cells growth inhibition, while in the samples exposed to the highest concentration (0.355 and 0.443mg/ml) no proliferation was register, suggesting cell death. MDA-MB-468 cell analysis showed similar responses. MDA-MB-231 demonstrated cell growth inhibition following the exposure to all analyzed high extract doses (0.117-0.443mg/ml). MDA-MB-468 cells were selected to evaluate the effect of fractions. In the samples exposed to the fraction containing the highest amount (91%) of oenothein B, at the concentration of 0.117mg/ml a pronounced cell growth inhibition while at higher concentrations (0.266 and 0.443mg/ml) no cell proliferation was observed. CONCLUSIONS: The consumption of C. angustifolium herb can be advantageous, alongside with conventional breast cancer treatment
Affiliation(s): Biochemijos katedra
Botanikos sodas
Instrumentinės analizės APC
Lietuvos sveikatos mokslų universitetas. Medicinos akademija
Lietuvos sveikatos mokslų universitetas. Medicinos akademija. Onkologijos institutas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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