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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Dressler, Cathrin;Schwandt, D;Beuthan, Jurgen;Mildažienė, Vida;Zabarylo, Urszula;Minet, Olaf
Title: Thermally induced changes of optical and vital parameters in human cancer cells
Is part of: Laser physics letters. Weinheim : WILEY-VCH Verlag GmbH, 2010, Vol. 7, iss. 11
Extent: p. 817-823
Date: 2010
Keywords: Audinių optika;Vėžinės lastelės;Termoterapija;Šilumos stresas;Tissue optics;Cancer cells;Thermotherapy;Thermal stress
Abstract: Minimally invasive laser-induced thermotherapy (LITT) presents an alternative method to conventional tumor therapeutically interventions, such as surgery, chemotherapy, radiotherapy or nuclear medicine. Optical tissue characteristics of tumor cells and their heat-induced changes are essential issues for controlling LITT progressions. Therefore, it is indispensable to exactly know the absorption coefficient μa, the scattering coefficient μs and the anisotropy factor g as well as their changes under rising temperatures in order to simulate the treatment parameters successfully. Optical parameters of two different cancer model tissues – breast cancer cells species MX1 and colon cancer cells species CX1 – were measured in the spectral range 400–1100 nm as well as in the temperature range 37–60°C. The absorption coefficient of both cell species was low throughout the spectral range analyzed, while μs of both species rose with increasing temperatures. The anisotropy factor g however dropped for both tissues with increasing temperatures. Light scatterings inside tissues proceeded continuously forward for all species tested. It was demonstrated that optical tissue properties undergo significant changes along with the vital status of the cells when the temperature increases
Affiliation(s): Aplinkos tyrimų centras
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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