Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/54296
Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Chemija / Chemistry (N003)
Author(s): Maruška, Audrius;Kornyšova, Olga
Title: Continuous beds (monoliths) : stationary phases for liquid chromatography formed using the hydrophobic interaction-based phase separation mechanism
Other Title: Ištisiniai sorbentai (monolitai): nejudrios fazės skysčių chromatografijai, gautos naudojant hidrofobine sąveika pagrįstą fazių atsiskyrimo mechanizmą
Is part of: Journal of biochemical and biophysical methods. Amsterdam : Elsevier B.V., 2004, Vol. 59, iss. 1
Extent: p. 1-48
Date: 2004
Keywords: Acrylamide-acrylate monomers;Continuous bed;Monolith;Rotaxane;Restricted-access media;Stationary phases;Gels;Microchips;HPLC;cLC;CEC
Abstract: The pioneering research work published by Hjertén et al. [J. Chromatogr. 473 (1989) 273] in 1989 dealing with development and application of the continuous bed (monolithic) technique as an attractive alternative for the classical packed columns in chromatography, stimulated further investigations in this direction. The research data published since that time on the development and application of the continuous beds formed using hydrophobic interaction-based phase separation mechanism are reviewed. Some innovative species of the beds, such as polyrotaxane beds or nonparticulate restricted-access materials for direct analysis of the biological fluids in the capillary format are also discussed. Characteristic features and practical details of the continuous bed technique are revealed. Due to many advantages, the continuous bed technique became a competitor with the traditional packings in capillary or chip-based microanalysis. The importance of the continuous bed morphology on the chromatographic characteristics is shown. The applicability of modern microscopic analysis to evaluate the morphology of the continuous beds is demonstrated
Internet: https://doi.org/10.1016/j.jbbm.2003.12.003
Affiliation(s): Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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