Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/54117
Type of publication: research article
Type of publication (PDB): Straipsnis recenzuojamoje Lietuvos tarptautinės konferencijos medžiagoje / Article in peer-reviewed Lithuanian international conference proceedings (P1e)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Saulė, Rita;Saulis, Gintautas;Batiuškaitė, Danutė
Title: Influence of ascorbic acid on the efficiency of electrochemotherapy with bleomycin in vitro
Is part of: Biomedical engineering - 2010 : proceedings of International Conference, 28-29 October 2010, Kaunas University of Technology. Kaunas : Technologija, 2010
Extent: p. 175-178
Date: 2010
Abstract: Bleomycin alone was cytotoxic to mouse hepatoma MH-22A cells in vitro at concentrations above 10-20 nM. Exposure of cells to an electric pulse with the duration of 100 s and the amplitude of 2 kV/cm only did not reduce cell viability. Treatment of cells by an electric pulse in the presence of bleomycin greatly potentiated its cytotoxicity towards cells - the bleomycin concentration required to reduce cell survival by 50% was 3.8 nM only. It was obtained that the preincubation of mouse hepatoma MH-A22 cells with L-ascorbic acid at concentrations of 1 mM increased the number of electropermeabilized cells killed by bleomycin
Internet: https://hdl.handle.net/20.500.12259/54117
Affiliation(s): Biologijos katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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