Use this url to cite publication: https://hdl.handle.net/20.500.12259/54117
Influence of ascorbic acid on the efficiency of electrochemotherapy with bleomycin in vitro
Type of publication
Straipsnis recenzuojamoje Lietuvos tarptautinės konferencijos medžiagoje / Article in peer-reviewed Lithuanian international conference proceedings (P1e)
Title
Influence of ascorbic acid on the efficiency of electrochemotherapy with bleomycin in vitro
Is part of
Biomedical engineering - 2010 : proceedings of International Conference, 28-29 October 2010, Kaunas University of Technology. Kaunas : Technologija, 2010
Date Issued
| Date |
|---|
2010 |
Publisher
Kaunas : Technologija
Extent
p. 175-178
Abstract (en)
Bleomycin alone was cytotoxic to mouse hepatoma MH-22A cells in vitro at concentrations above 10-20 nM. Exposure of cells to an electric pulse with the duration of 100 s and the amplitude of 2 kV/cm only did not reduce cell viability. Treatment of cells by an electric pulse in the presence of bleomycin greatly potentiated its cytotoxicity towards cells - the bleomycin concentration required to reduce cell survival by 50% was 3.8 nM only. It was obtained that the preincubation of mouse hepatoma MH-A22 cells with L-ascorbic acid at concentrations of 1 mM increased the number of electropermeabilized cells killed by bleomycin.
Type of document
type::text::journal::journal article::research article
Language
Anglų / English (en)
Coverage Spatial
Lietuva / Lithuania (LT)
ISSN (of the container)
2029-3380
Other Identifier(s)
VDU02-000009201