Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/53001
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dc.contributor.authorMaciulevičius, Martynas-
dc.contributor.authorTamošiūnas, Mindaugas-
dc.contributor.authorJakštys, Baltramiejus-
dc.contributor.authorJurkonis, Rytis-
dc.contributor.authorVenslauskas, Mindaugas Saulius-
dc.contributor.authorŠatkauskas, Saulius-
dc.coverage.spatialUS-
dc.date.accessioned2018-10-06T23:40:48Z-
dc.date.available2018-10-06T23:40:48Z-
dc.date.issued2016-
dc.identifier.issn03015629-
dc.identifier.otherVDU02-000020208-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0301562916302174-
dc.identifier.urihttp://www.umbjournal.org/article/S0301-5629(16)30217-4/fulltext-
dc.description.abstractIn the present study, microbubble (MB) cavitation signal analysis was performed together with calcein release evaluation in both pressure and exposure duration domains of the acoustic field. A passive cavitation detection system was used to simultaneously measure MB scattering and attenuation signals for subsequent extraction efficiency relative to MB cavitation activity. The results indicate that the decrease in the efficiency of extraction of calcein molecules from Chinese hamster ovary cells, as well as cell viability, is associated with MB cavitation activity and can be accurately predicted using inertial cavitation doses up to 0.18 V × s (R2 > 0.9, p < 0.0001). No decrease in additional calcein release or cell viability was observed after complete MB sonodestruction was achieved. This indicates that the optimal exposure duration within which maximal sono-extraction efficiency is obtained coincides with the time necessary to achieve complete MB destruction. These results illustrate the importance of MB inertial cavitation in the sono-extraction process. To our knowledge, this study is the first to (i) investigate small molecule extraction from cells via sonoporation and (ii) relate the extraction process to the quantitative characteristics of MB cavitation acoustic spectraen
dc.description.sponsorshipBiologijos katedra-
dc.description.sponsorshipGamtos mokslų fakultetas-
dc.description.sponsorshipKauno technologijos universitetas-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 2990-3000-
dc.language.isoen-
dc.relation.ispartofUltrasound in medicine and biology. New York, NY : Elsevier, 2016, vol. 42, iss. 12-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyBIOSIS Previews-
dc.relation.isreferencedbyCurrent Contents / Clinical Medicine-
dc.relation.isreferencedbyAcademic Search Alumni Edition (EBSCO)-
dc.relation.isreferencedbyAcademic Search Complete (EBSCO)-
dc.relation.isreferencedbyAcademic Search Elite (EBSCO)-
dc.relation.isreferencedbyAcademic Search Premier (EBSCO)-
dc.relation.isreferencedbyAcademic Search R&D (EBSCO)-
dc.relation.isreferencedbyScienceDirect-
dc.subjectSonoporacijalt
dc.subjectKalceinaslt
dc.subjectInercinės kavitacijos dozėlt
dc.subjectAteniuacijalt
dc.subjectMikroburbulailt
dc.subjectSonoporationen
dc.subjectCalceinen
dc.subjectExtractionen
dc.subjectInertial cavitation doseen
dc.subjectAttenuationen
dc.subjectMicrobubbleen
dc.subject.classificationStraipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)-
dc.subject.otherBiologija / Biology (N010)-
dc.titleInvestigation of microbubble cavitation-induced calcein release from cells in vitroen
dc.typeresearch article-
dc.identifier.doihttps://doi.org/10.1016/j.ultrasmedbio.2016.08.005-
dc.identifier.isiWOS:000389549300028-
dcterms.bibliographicCitation51-
dc.date.updated2020-02-07T14:30Z-
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local.typeS-
item.fulltextWith Fulltext-
item.grantfulltextopen-
crisitem.author.deptBiologijos katedra-
crisitem.author.deptBiologijos katedra-
crisitem.author.deptBiochemijos katedra-
crisitem.author.deptTarptautinių ryšių departamentas-
crisitem.author.deptBiologijos katedra-
crisitem.author.deptBiologijos katedra-
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications
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