Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/52839
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dc.contributor.authorSutkuvienė, Simona-
dc.contributor.authorSakalauskaitė, Sandra-
dc.contributor.authorDaugelavičius, Rimantas-
dc.coverage.spatialLT-
dc.date.accessioned2018-10-06T23:38:52Z-
dc.date.available2018-10-06T23:38:52Z-
dc.date.issued2016-
dc.identifier.issn23358653-
dc.identifier.otherVDU02-000020023-
dc.identifier.urihttp://vns.microsep.org/wp-content/uploads/2016/06/vns2016VK.pdf-
dc.description.abstractAntibiotics are considered the keystone of modern medicine, but their excessive use gives the consequences. Frequent usage of it for human therapy, as well as for farm animals resulted pathogenic bacteria resistance to multiple drugs. Multidrug resistance MDR efflux pumps are the main reason of bacterial resistance to antibiotics. Inhibitors of drug efflux pumps have great potential as pharmacological agents that restore the drug susceptibility of multidrug resistant bacterial pathogens. The idea to investigate phenothiazine derivatives as efflux pump inhibitors derived from the previous studies of methylene blue and chlorpromazine antimicrobial activity against infectious bacteria. It is very important to discover molecules which inhibit efflux pumps and to investigate the mechanism of efflux pump inhibition. The aim of our work was to evaluate the inhibition efficiency of various phenothiazine derivatives of MDR efflux pumps in bacteria cells. In this work we studied effects of the phenothiazine based MDR efflux pump inhibitors on the accumulation of TPP⁺ ions in different bacteria. Data on the effective concentrations of the phenothiazine inhibitors and the efficiency of inhibition of MDR efflux pump activity will be presenteden
dc.description.sponsorshipBiochemijos katedra-
dc.description.sponsorshipGamtos mokslų fakultetas-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 96-96-
dc.language.isoen-
dc.relation.ispartofThe vital nature sign [electronic resource] : 10th international scientific conference, May 19-20, 2016 Vilnius, Lithuania : abstract book. Kaunas : Vytautas Magnus university, 2016, [no. 10]-
dc.subjectAntibioticsen
dc.subjectPhenothiazinesen
dc.subjectMultidrug resistanceen
dc.subjectEfflux pump inhibitorsen
dc.subject.classificationTezės kituose recenzuojamuose leidiniuose / Theses in other peer-reviewed publications (T1e)-
dc.subject.otherBiochemija / Biochemistry (N004)-
dc.titleEfficiency evaluation of phenothiazine-based inhibitors of MDR efflux pumps in gram-negative bacteria cellsen
dc.typeconference paper-
dcterms.bibliographicCitation0-
dc.date.updated2016-10-14T14:49Z-
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local.typeT-
item.fulltextWith Fulltext-
item.grantfulltextopen-
crisitem.author.deptBiochemijos katedra-
crisitem.author.deptBiochemijos katedra-
crisitem.author.deptBiochemijos katedra-
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications
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