Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/51830
Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Teologija / Theology (H002)
Author(s): Serapinas, Danielius;Narbekovas, Andrius;Juškevičius, Jonas;Sakalauskas, Raimundas
Title: Systemic inflammation in COPD in relation to smoking status
Is part of: Multidisciplinary respiratory medicine : official scientific journal of AIMAR. Borgomanero : Novamedia, 2011, vol. 6, no. 4
Extent: p. 214-219
Date: 2011
Keywords: Alfa-1 antitripsinas;Uždegimo žymenys;LOPL;Alpha-1 antitrypsin;Inflammatory markers;COPD
Abstract: Background and aims: Smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD) that has been recently defined as a systemic pulmonary inflammatory disease. However, the impact of smoking itself on systemic inflammation in COPD patients has not yet been well established. The aim of our study was to investigate the association between inflammatory markers and smoking status. Material and methods:We compared 202 current smokers, 61 ex-smokers and 57 never-smokers, all COPD patients. Assessments included medical history, spirometry, alpha-1 antitrypsin (AAT) genotyping, serum AAT, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and soluble tumor necrosis factor receptor (sTNFR)-1 and sTNFR-2 concentrations. Results: AAT and CRP concentrations in smokers (1.75 ± 0.51 g/L and 14.4 [9.5–20.5] mg/L) and ex-smokers (1.69 ± 0.43 g/L and 12.3 [8.7–16.3] mg/L) were higher than in never-smokers (1.49 ± 0.38 g/L and 5.1 [2.5–8.7] mg/L; p < 0.05). sTNFR-1 level was higher in smokers than ex-smokers or never-smokers (241.2 pg/mL [145.3–349.4] vs. 213.7 pg/mL [147.1– 280.3] and 205.2 pg/mL [125–275]; p < 0.05).[...]
Internet: http://www.mruni.eu/upload/c43/MRM%2004-2011_defbassaj1p.pdf
Affiliation(s): Lietuvos sveikatos mokslų universitetas
Lietuvos sveikatos mokslų universitetas, raimundas.sakalauskas@kmuk.lt
Mykolo Romerio universitetas
Mykolo Romerio universitetas, jjusk@mruni.eu
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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