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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science Master Journal List / Article in Clarivate Analytics Web of Science Master Journal List (S2)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Žūkienė, Rasa;Naučienė, Zita;Degutytė-Fomins, Laima;Mildažienė, Vida
Title: Gender-dependence of hyperthermia-induced changes in respiration of rat liver mitochondria
Other Title: Hipertermijos sukeltų žiurkės kepenų mitochondrijų kvėpavimo greičio pokyčių priklausomybė nuo lyties
Is part of: Biologija. Vilnius : Lietuvos mokslų akademijos leidykla, 2010, Vol. 56, nr. 1-4
Extent: p. 88-92
Date: 2010
Keywords: Kepenų mitochondrijos;Hipertermija;Lytinis dimorfizmas;Liver mitochondria;Hyperthermia;Gender (sexual) dimorphism
Abstract: Šiame darbe siekta įvertinti hipertermijos poveikį iš skirtingos lyties žiurkių kepenų išskirtų mitochondrijų kvėpavimui. Palyginome karščiavimo temperatūros (40 °C) ir suprafiziologinio kaitinimo poveikį (41–46 °C) mitochondrijų, išskirtų iš žiurkių patinų ir patelių, kvėpavimo greičiui esant antrai (V2) ir trečiai metabolinei būsenai (V3). Gautais duomenimis, karščiavimo temperatūra aktyvino patelių ir slopino patinų mitochondrijų kvėpavimą esant trečiai metabolinei būsenai.[...]
The effect of hyperthermia on the respiration of liver mitochondria derived from animals of different genders was estimated. We compared the effect of heating in the febrile (40 °C) and supraphysiological (41–46 °C) temperature range on the respiration rate in metabolic state 2 (V2) and state 3 (V3) of isolated mitochondria derived from male and female rat liver. Our results indicate that an increase of temperature in the fever range activates female but inhibits male liver mitochondrial respiration in state 3. Female mitochondria are less sensitive to supraphysiological temperature hyperthermia (41–43 °C). However, a severe hyperthermia (44–46 °C) strongly inhibits and uncouples oxidative phosphorylation in mitochondria, but the temperature-induced increase in inner membrane permeability is stronger in female mitochondria. At 46 °C, independently of gender, mitochondria are completely uncoupled (V2 = V3) and are unable to phosphorylate ADP. The increased respiration rate in the uncoupled state proves that febrile temperature (40 °C) activates oxidation processes in liver mitochondria isolated from female rats. For this reason, at 40 °C the respiratory control index (RCI) decreases to a much lower extent in mitochondria derived from female liver
Affiliation(s): Aplinkos tyrimų centras
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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