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Type of publication: conference paper
Type of publication (PDB): Tezės kituose recenzuojamuose leidiniuose / Theses in other peer-reviewed publications (T1e)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Mikalayeva, Valeryia;Daugelavičius, Rimantas
Title: Effect of phenylalanine-arginine beta-naphthylamide on minimal inhibitory concentration of antibiotics in the case of salmonella enterica cells
Is part of: The vital nature sign [elektroninis išteklius] : 7-th international scientific conference : abstract book. Kaunas : Vytautas Magnus university, 2013, [no. 7]
Extent: p. 14-14
Date: 2013
Abstract: Resistance to antibiotics is the very common problem in medicine. It is important to understand the mechanisms of multidrug resistance in bacteria. We focused our study on efflux pump system using method of microdilutions. We used Salmonella enterica SL1344 (WT), L664 and ΔacrB strains to determine influence of phenylalanine-arginine β-naphthylamide (PAβN) on MICs of ampicillin, chloramphenicol and tetracycline. PAβN is very popular inhibitor of RND-type efflux pumps. It is toxic for bacterial cells only at high concentrations. We showed that low inactive concentrations of antibiotics can inhibit bacterial growth in combination with PAβN. Our results indicate that inhibitory activity of PAβN depends on the initial bacterial cell concentration. Such results suggest intensive binding of PAβN by the cells
Affiliation(s): Biochemijos katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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