Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/48029
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dc.contributor.authorMildažienė, Vida-
dc.contributor.authorNaučienė, Zita-
dc.contributor.authorKrab, Klaas-
dc.coverage.spatialNL-
dc.date.accessioned2018-10-06T21:53:31Z-
dc.date.available2018-10-06T21:53:31Z-
dc.date.issued2002-
dc.identifier.issn03014851-
dc.identifier.otherVDU02-000008550-
dc.identifier.otherIDS: 592QJ-
dc.identifier.urihttp://springerlink.metapress.com/content/g232512351160211/fulltext.pdf-
dc.description.abstractThe response of the respiratory subsystem of oxidative phosphorylation to the environmental pollutant, 2,2',5,5'-tetrachlorobiphenyl (2,2',5,5'-TCB) was investigated by modular kinetic approach. The effects of 20 microM 2,2',5,5'-TCB on the activity of the respiratory chain modules in rat liver mitochondria oxidizing succinate (+ rotenone) in state 3 were assessed. The toxin inhibited the rate of respiration by 23%. Analysis around cytochrome c revealed that 2,2',5,5'-TCB inhibited both cytochrome c-oxidizing and reducing modules. The toxin inhibited also CoQ-oxidizing module, however it did not affect the kinetics of CoQ-reducing module. Taken together, these data indicated that 2,2',5,5'-TCB inhibited cytochrome bc1 but had no effect on succinate dehydrogenaseen
dc.description.sponsorshipInstitute for Biomedical Research, Kaunas Medical University-
dc.description.sponsorshipKauno medicinos universiteto Biomedicininių tyrimų institutas-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 31-34-
dc.language.isoen-
dc.relation.ispartofMolecular biology reports. , 2002, vol. 29, no. 1-2-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyScopus-
dc.subject.classificationStraipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)-
dc.subject.otherBiologija / Biology (N010)-
dc.titleThe targets of 2,2',5,5'-tetrachlorobiphenyl in the respiratory chain of rat liver mitochondria revealed by modular kinetic analysisen
dc.typeresearch article-
dc.date.updated2014-12-01T13:00Z-
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local.typeS-
item.fulltextNo Fulltext-
item.grantfulltextnone-
crisitem.author.deptBiochemijos katedra-
crisitem.author.deptBiochemijos katedra-
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications
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