Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMildažienė, Vida-
dc.contributor.authorNaučienė, Zita-
dc.contributor.authorKrab, Klaas-
dc.identifier.otherIDS: 592QJ-
dc.description.abstractThe response of the respiratory subsystem of oxidative phosphorylation to the environmental pollutant, 2,2',5,5'-tetrachlorobiphenyl (2,2',5,5'-TCB) was investigated by modular kinetic approach. The effects of 20 microM 2,2',5,5'-TCB on the activity of the respiratory chain modules in rat liver mitochondria oxidizing succinate (+ rotenone) in state 3 were assessed. The toxin inhibited the rate of respiration by 23%. Analysis around cytochrome c revealed that 2,2',5,5'-TCB inhibited both cytochrome c-oxidizing and reducing modules. The toxin inhibited also CoQ-oxidizing module, however it did not affect the kinetics of CoQ-reducing module. Taken together, these data indicated that 2,2',5,5'-TCB inhibited cytochrome bc1 but had no effect on succinate dehydrogenaseen
dc.description.sponsorshipInstitute for Biomedical Research, Kaunas Medical University-
dc.description.sponsorshipKauno medicinos universiteto Biomedicininių tyrimų institutas-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 31-34-
dc.relation.ispartofMolecular biology reports. , 2002, vol. 29, no. 1-2-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.subject.classificationStraipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)-
dc.subject.otherBiologija / Biology (N010)-
dc.titleThe targets of 2,2',5,5'-tetrachlorobiphenyl in the respiratory chain of rat liver mitochondria revealed by modular kinetic analysisen
dc.typeresearch article-
local.object{"source": {"code": "vdu", "handle": "8550"}, "publisher": {"list": false}, "db": {"clarivate": true, "scopus": true, "list": true}, "issn": ["0301-4851"], "code": "S1", "subject": ["N010"], "url": [""], "country": "NL", "language": "en", "area": "N", "original": true, "pages": 4, "sheets": 0.286, "timestamp": "20141201130042.0", "account": {"year": 2002, "late": false}, "na": 3, "nip": 0, "affiliation": [{"contribution": 0.33333333333333, "aip": 2, "rel": "aut", "org": [{"create": false, "contribution": 0.16666666666667, "name": "Institute for Biomedical Research, Kaunas Medical University", "id": "111951683"}, {"create": true, "contribution": 0.16666666666667, "name": "Vytauto Didžiojo universitetas", "id": "111950396", "level": "0", "type": "uni", "research": "1", "status": "1"}], "id": "6741CBC752C256C5B8AADDCCAA809C48", "lname": "Mildažienė", "fname": "Vida", "status": "1", "orcid": "0000-0001-8768-0253", "name": "Mildažienė, Vida"}, {"contribution": 0.33333333333333, "aip": 2, "rel": "aut", "org": [{"create": true, "contribution": 0.16666666666667, "name": "Vytauto Didžiojo universitetas", "id": "111950396", "level": "0", "type": "uni", "research": "1", "status": "1"}, {"create": false, "contribution": 0.16666666666667, "name": "Kauno medicinos universiteto Biomedicininių tyrimų institutas", "id": "111957412"}], "id": "7E3E71B0CA875BFBAF740C30DC55AF7D", "lname": "Naučienė", "fname": "Zita", "status": "1", "orcid": "0000-0002-7460-2616", "name": "Naučienė, Zita"}, {"contribution": 0.33333333333333, "aip": 1, "rel": "aut", "lname": "Krab", "fname": "Klaas", "status": "0", "name": "Krab, Klaas"}]}-
item.fulltextNo Fulltext-
item.grantfulltextnone- katedra- katedra-
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications
Show simple item record
Export via OAI-PMH Interface in XML Formats
Export to Other Non-XML Formats

CORE Recommender

Page view(s)

checked on Jun 6, 2021


checked on Jun 6, 2021

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.