Use this url to cite publication: https://hdl.handle.net/20.500.12259/47987
Tetraphenylphosphonium inhibits oxidation of physiological substrates in heart mitochondria
Type of publication
Straipsnis Web of Science duomenų bazėje / Article in Web of Science database (S1a)
Author(s)
Author | Affiliation | |
---|---|---|
Kauno medicinos universiteto Biomedicininių tyrimų institutas | ||
Title [en]
Tetraphenylphosphonium inhibits oxidation of physiological substrates in heart mitochondria
Is part of
Molecular and cellular biochemistry. Dordrecht : Kluwer Academic, 1997, vol. 174, no. 1-2
Date Issued
Date |
---|
1997 |
Publisher
Dordrecht : Kluwer Academic
Is Referenced by
Extent
p. 67-70
Abstract (en)
We show that tetraphenylphosphonium inhibits oxidation of palmitoylcarnitine, pyruvate, malate, 2-oxoglutarate and glutamate in heart mitochondria in the range of concentration (1-5 mu M) commonly used for the determination of mitochondrial membrane potential. The inhibition of 2-oxoglutarate (but not other substrate) oxidation by tetraphenylphosphonium is dependent on the concentration of 2-oxoglutarate and on extramitochondrial free calcium, and the kinetic plots are consistent with a mixed type of inhibition. Our results indicate that tetraphenylphosphonium interacts with enzymes, specifically involved in the oxidation of 2-oxoglutarate, most possibly, 2-oxoglutarate dehydrogenase.
Type of document
type::text::journal::journal article::research article
Language
Anglų / English (en)
Coverage Spatial
Nyderlandai / Netherlands (NL)
ISSN (of the container)
0300-8177
Other Identifier(s)
VDU02-000008574
IDS Number: XW621
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
MOLECULAR AND CELLULAR BIOCHEMISTRY | 1.345 | 0 | 0 | 0 | 2 | 0 | 1997 | Q3 |
Journal | IF | AIF | AIF (min) | AIF (max) | Cat | AV | Year | Quartile |
---|---|---|---|---|---|---|---|---|
MOLECULAR AND CELLULAR BIOCHEMISTRY | 1.345 | 0 | 0 | 0 | 2 | 0 | 1997 | Q3 |