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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Biologija / Biology (N010)
Author(s): Tamošiūnas, Mindaugas;Jurkonis, Rytis;Mir, Lluis M;Lukoševičius, Arūnas;Venslauskas, Mindaugas Saulius;Šatkauskas, Saulius
Title: Microbubble sonodestruction rate as a metric to evaluate sonoporation efficiency
Is part of: Journal of ultrasound in medicine. Laurel, MD : American Institute of Ultrasound in Medicine, 2012, vol. 31, no. 12
Extent: p. 1993-2000
Date: 2012
Keywords: Words bleomycin;Dosimetry;Microbubble;Sonodestruction
Abstract: Objectives. The efficiency of sonoporation is directly related to microbubble cavitation and can be dependent on the microbubble sonodestruction rate. The objective of this study was to investigate whether the rate of microbubble sonodestruction can be used as a parameter to develop an implicit dosimetric method for sonoporation efficiency evaluation. Methods. To evaluate the rate of microbubble sonodestruction as a function of the ultrasound (US) peak negative ultrasound pressure, 12-MHz diagnostic US was used in the B-scan mode. Chinese hamster ovary cells were exposed to therapeutic US at 880 kHz in the absence or presence of microbubbles. The sonoporation efficiency was evaluated by the sonotransfer of bleomycin, a cytotoxic, membrane-impermeable anticancer drug. Results. At a low microbubble sonodestruction rate of 1/τ < 0.5 second–1 (τ providing the time necessary to decrease the microbubble concentration to 37% of its initial value), cell viability remained basically unaffected, but the percentage of sonoporated cells did not reach 10%. At higher microbubble sonodestruction rates, the efficiencies of irreversible and reversible sonoporation started to increase linearly and reached the plateau at 5 seconds–1. Conclusions. These results show that the microbubble sonodestruction rate can be used to predict the percentage of reversible and irreversible sonoporation
Affiliation(s): Biologijos katedra
Kauno technologijos universitetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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