Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/46945
Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Biologija / Biology (N010)
Author(s): Naučienė, Zita;Žūkienė, Rasa;Degutytė-Fomins, Laima;Mildažienė, Vida
Title: Mitochondrial membrane barrier function as a target of hyperthermia
Is part of: Medicina. Kaunas : Lietuvos sveikatos mokslų universitetas, 2012, T. 48, nr. 5
Extent: p. 249-255
Date: 2012
Keywords: Mitochondrijos;Membranaos laidumas;Hipertermija;Hiperterminė perfuzija;Modulių kinetinė analizė;Mitochondria;Membrane permeability;Hyperthermia;Hyperthermic perfusion;Modular kinetic analysis
Abstract: Hyperthermia is a promising modality for cancer treatment that urgently requires detailed knowledge on molecular and cellular processes for the rational development of treatment protocols. The thorough study of the response of the inner membrane of heart and liver mitochondria to hyperthermia was performed in order to establish the pattern of the hyperthermia-induced changes in the membrane barrier function. Material and Methods. The isolated mitochondria from rat heart and liver (of both genders) were used for experiments, as well as mitochondria isolated from the perfused male rat liver. Changes in the membrane permeability were evaluated by mitochondrial respiration in state 2 or by estimation of the modular kinetics of the membrane leak. Results. The inner membrane of isolated mitochondria from healthy tissues was found to be an extremely sensitive target of hyperthermia that exerted the response even in the febrile range. More severe hyperthermia compromised the inner mitochondrial membrane function; however, this response was tissue-specific and, to some extent, gender-dependent (for liver mitochondria). The data obtained by direct heating of isolated mitochondria were validated by experiments on the perfused liver. Conclusions. The obtained results imply a crucial importance of the evaluation of the tissue- and gender-specific differences while developing or improving the protocols for hyperthermic treatment or combinatory therapy
Internet: http://medicina.kmu.lt/1205/1205-04e.pdf
Affiliation(s): Biochemijos katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

Files in This Item:
marc.xml11.67 kBXMLView/Open

MARC21 XML metadata

Show full item record
Export via OAI-PMH Interface in XML Formats
Export to Other Non-XML Formats


CORE Recommender

WEB OF SCIENCETM
Citations 1

8
checked on Feb 27, 2021

Page view(s)

134
checked on Feb 3, 2020

Download(s)

12
checked on Feb 3, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.