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Type of publication: research article
Type of publication (PDB): Straipsnis recenzuojamoje Lietuvos tarptautinės konferencijos medžiagoje / Article in peer-reviewed Lithuanian international conference proceedings (P1e)
Field of Science: Biologija / Biology (N010)
Author(s): Tamošiūnas, Mindaugas;Čepurnienė, Karolina;Šatkauskienė, Ingrida;Jurkonis, Rytis;Šatkauskas, Saulius
Title: The microbubble concentration study for the sonoporation efectiveness in vitro
Other Title: Mikroburbuliukų koncentracijos poveikio sonoporacijos efektyvumui in vitro tyrimas
Is part of: Virtualūs instrumentai biomedicinoje 2009 : tarptautinės mokslinės-praktinės konferencijos pranešimų medžiaga. Klaipėda : Klaipėdos universiteto leidykla, 2009
Extent: p. 80-87
Date: 2009
Keywords: Sonoporacija;Ultragarsas;Kontrastinis agentas;Mikroburbulai;Sonoporation;Ultrasound;Contrast agent;Microbubbles
ISBN: 9789955184249
Abstract: Ultrasound can temporally increase the permeability of cell membrane, facilitating the access of exogenous molecules into the cells and tissues. The phenomenon is also known as sonoporation. Sonoporation in vitro is most effective when the ultrasonic energy is used to amplify the oscillation and collapse of the microbubbles induced by ultrasound contrast agent. In this study, we used CHO cells to investigate the effectiveness of sonoporation in vitro, in the presence of SonoVue microbubbles at 0 and 3 h post preparation. Our results showed that the instantaneous microbubble concentration decreased exponentially and dropped down to 10 % at 3 hours. The effectiveness of sonoporation was observed to be largely dependent on the microbubble concentration. Consistently with the decrease of microbubble concentration, the number of sonoporated cells was also decreased, demonstrating the importance of the effective concentration of microbubbles
Affiliation(s): Biologijos katedra
Kauno technologijos universitetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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