Synthesis of reversed phase continuous bed (monolith): optimization of efficiency and hydrophobicity

Abstract

The main advantages of synthesis of polymeric continuous bed are: 1) in situ polymerization; 2) no need of frits is required and 3) morphology of continuous bed is formed during polymerization. Because morphology is formed during polymerization, parameters governing phase separation and morphology have to be strictly controlled. During polymerization of continuous beds with porogens usually is controlled: total monomer concentration and total crosslinker concentration, porogen type and composition, polymerization temperature and time etc [1]. In case of water based polymerization media, during polymerization is controlled: total monomer concentration and total crosslinker concentration, polymerization media concentration (ionic strength), type and pH, polymerization temperature and time etc [2, 3]. [...]