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Type of publication: research article
Type of publication (PDB): Straipsnis recenzuojamoje Lietuvos tarptautinės konferencijos medžiagoje / Article in peer-reviewed Lithuanian international conference proceedings (P1e)
Field of Science: Biologija / Biology (N010)
Author(s): Antanavičiūtė, Ieva;Žūkienė, Rasa;Buzaitė, Odeta;Naučienė, Zita;Degutytė-Fomins, Laima;Kalvelytė, Audronė;Mildažienė, Vida;Skeberdis, Vytenis Arvydas
Title: Genetic modification of skeletal myoblast with connexin 43 and Akt genes enhances cell resistance to hyperthermic and oxidative stress
Is part of: The Vital Nature Sign : 3rd International Conference, Kaunas, Lithuania, May 22-23, 2009 : proceedings. Kaunas : Vytautas Magnus university, 2009
Extent: p. 108-109
Date: 2009
Keywords: Genetic modification;Skeletal myoblast;Akt genes
ISBN: 9789955125426
Abstract: Our current project is concerned with application of cellular therapy for heart repair after experimentally induced infarction in rabbit’s heart. For transplantation into damaged myocardium we use autologic skeletal myoblasts [1]. One of the major problems is the survival and electrical integration of implanted myoblasts. Therefore, before transplantation we transfect the myoblasts with connexin43 (Cx43) or protein kinase B (Akt) genes which are expected to improve cell-to-cell coupling, prevent the incidence of ventricular tachyarrhythmias and improve antiapoptotic properties of myoblasts [2]. Since the transplantation of the cells is often followed by inflammation and other cardiotoxic processes, we examined the resistance of control and Cx43 or Akt transfected cells to hyperthermic shock and to exogenous active oxigen species (H2O2). Also we demonstrated that non-invasive measurement of NAD(P)H fluorescence in vivo could be used for evaluation of viability of damaged cardiac muscle after cellular therapy. [...]
Affiliation(s): Aplinkos tyrimų centras
Aplinkotyros katedra
Biochemijos institutas
Biochemijos katedra
Biologijos katedra
Kauno medicinos universiteto Kardiologijos institutas
Kauno medicinos universiteto Kardiologijos institutas,
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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