Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/45046
Type of publication: conference paper
Type of publication (PDB): Konferencijų tezės nerecenzuojamuose leidiniuose / Conference theses in non-peer-reviewed publications (T2)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Lengvinaitė, Simona;Daugelavičius, Rimantas
Title: Synthesis and efficiency evaluation of RND type efflux pump inhibitors
Is part of: New compounds and new strategies for antimicrobials : new antimicrobials project, 2nd workshop, University of Trieste, 25-26 May, 2012 : [abstracts]. Trieste, Italy : University of Trieste, 2012
Extent: p. 38-38
Date: 2012
Keywords: Efficiency;RND-type efflux;Pump inhibitors
Abstract: Salmonella enterica serovar Typhimurium is the main cause of food poisoning and is the second most common cause of bacterial diarrhea. RND-type multidrug resistance efflux pumps are the main reason of Salmonella enterica cell resistance to antibiotics. It is important to investigate the mechanism of efflux pump inhibition. The aim of our work was to synthesize small dipeptide inhibitors and to evaluate the efficiency RND-type efflux pump inhibition in S. enterica cells. In this work we present data on the electrochemical assay of accumulation of an indicator compound of efflux pumps in bacteria tetraphenylphosphonium (TPP⁺) ions. We studied effects of the synthesized RND-type efflux pump inhibitors on accumulation of TPP⁺ ions in S. enterica. Data on the effective concentrations of the inhibitors and the efficiency of inhibition of RND-type efflux pump activity will be presented
Internet: https://hdl.handle.net/20.500.12259/45046
Affiliation(s): Biochemijos katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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