Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/44238
Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Biofizika / Biophysics (N011)
Author(s): Saulis, Gintautas;Venslauskas, Mindaugas Saulius
Title: Cell electroporation .1. Theoretical simulation of the process of pore formation in a cell
Is part of: Bioelectrochemistry and bioenergetics. Lausanne : Elsevier, 1993, vol. 32, no. 3
Extent: p. 221-235
Date: 1993
Keywords: Ląstelių elektroporacijos teorija;Ląstelių elektroporacija;Membranos hidrofilinės poros;Cell electroporation;Theory of electroporation;Hydrophilic pores in membranes
Abstract: A kinetic model of cell electroporation is presented. The creation and resealing of metastable pores are described as random one-step processes. Two cases are analysed: A, the transmembrane potential DELTAPHI(m) is the same at all points on the cell surface; B, DELTAPHI(m) produced by an external electric field depends on the membrane site. On the basis of the presented model, the following characteristics of cell electroporation for these two cases are obtained: (i) the dependences of the probability that a cell is porated, F(p), and the average number of pores per cell, nBAR, on the pulse duration tau(i) at a fixed electric field strength E0, i.e. F(p)(tau(i)) and nBAR(tau(i)); (ii) the dependences of F(p) and nBAR on the field strength E0 at a fixed pulse length tau(i), i.e. F(p)(E0) and nBAR(E0). General equations describing the dependences of F(p) and nBAR on both parameters, i.e. F(p)(E0, tau(i)) and nBAR(E0, tau(i)), are also derived
Internet: https://doi.org/10.1016/0302-4598(93)80047-X
Affiliation(s): Gamtos mokslų fakultetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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