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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Kornyšova, Olga;Jarmalavičienė, Reda;Maruška, Audrius
Title: A simplified synthesis of polymeric nonparticulate stationary phases with macrocyclic antibiotic as chiral selector for capillary electrochromatography
Other Title: Paprastesnė polimerinių nebirių nejudrių fazių su makrociklinio antibiotiko chiraliniu selektoriumi, skirtų elektrochromatografijai, sintezė
Is part of: Electrophoresis. Special Issue: Paper Symposium Enantioseparations. Weinheim: Wiley-VCH Verlag GmbH & Co, 2004, Vol. 25, iss. 16
Extent: p. 2825-2829
Date: 2004
Keywords: Capillary electrochromatography;Continuous bed;Monolithic;Vancomycin chiral stationary phase
Abstract: A simplified approach to synthesize nonparticulate (continuous or monolithic) beds with embedded vancomycin chiral selectors for capillary electrochromatography is proposed. In the present approach, N,N'-diallyltartardiamide monomer with diol functionality is used, which can be readily converted to aldehyde groups via periodate treatment. Parallel to the activation of the polymeric matrix for covalent attachment of vancomycin, the periodate treatment has shown secondary effects on the polymeric bed morphology, namely the increase of the average pore size and porosity of the skeleton. Inversed size-exclusion chromatography was applied to characterize porosimetric properties of the capillary columns before and after the periodate treatment. Electroosmotic and enantioselective properties of the nonparticulate beds synthesized are presented. The approach is of more general interest attaching different affinity groups to the polymeric matrix and/or enhancing the accessibility to the active sites, for instance, in the molecular imprinting technique
Affiliation(s): Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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