Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/42919
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dc.contributor.authorLioy, Virginia S-
dc.contributor.authorMachon, Cristina-
dc.contributor.authorTabone, Mariangela-
dc.contributor.authorGonzalez-Pastor, José E-
dc.contributor.authorDaugelavičius, Rimantas-
dc.contributor.authorAyora, Silvia-
dc.contributor.authorAlonso, Juan C-
dc.coverage.spatialUS-
dc.date.accessioned2018-10-06T19:25:58Z-
dc.date.available2018-10-06T19:25:58Z-
dc.date.issued2012-
dc.identifier.issn19326203-
dc.identifier.otherVDU02-000011730-
dc.identifier.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0030282-
dc.description.abstractThe ζε module consists of a labile antitoxin protein, ε, which in dimer form (ε2) interferes with the action of the long-living monomeric ζ phosphotransferase toxin through protein complex formation. Toxin ζ, which inhibits cell wall biosynthesis and may be bactericide in nature, at or near physiological concentrations induces reversible cessation of Bacillus subtilis proliferation (protective dormancy) by targeting essential metabolic functions followed by propidium iodide (PI) staining in a fraction (20–30%) of the population and selects a subpopulation of cells that exhibit non-inheritable tolerance (1–5×10−5). Early after induction ζ toxin alters the expression of ~78 genes, with the up-regulation of relA among them. RelA contributes to enforce toxin-induced dormancy. At later times, free active ζ decreases synthesis of macromolecules and releases intracellular K+. We propose that ζ toxin induces reversible protective dormancy and permeation to PI, and expression of ε2 antitoxin reverses these effects. At later times, toxin expression is followed by death of a small fraction (~10%) of PI stained cells that exited earlier or did not enter into the dormant state. Recovery from stress leads to de novo synthesis of ε2 antitoxin, which blocks ATP binding by ζ toxin, thereby inhibiting its phosphotransferase activityen
dc.description.sponsorshipBiochemijos katedra-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 1-12-
dc.language.isoen-
dc.relation.ispartofPLoS ONE [elektroninis išteklius]. San Francisco, USA : Public Library of Science, 2012, vol. 7, iss. 1-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyZoological Record-
dc.relation.isreferencedbyBIOSIS Previews-
dc.relation.isreferencedbyMEDLINE-
dc.relation.isreferencedbyPubMed-
dc.relation.isreferencedbyScopus-
dc.subjectToxin ζen
dc.subjectAntitoxin proteinen
dc.subjectTA moduleen
dc.subject.classificationStraipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)-
dc.subject.otherBiochemija / Biochemistry (N004)-
dc.titleThe ζ toxin induces a set of protective responses and dormancyen
dc.typeresearch article-
dc.identifier.isiWOS:000301640600023-
dcterms.bibliographicCitation64-
dc.date.updated2020-02-03T16:31Z-
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local.typeS-
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptBiochemijos katedra-
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications
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