Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/41735
Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Biologija / Biology (N010)
Author(s): Gonthier, Bertrand;Koncina, Eric;Šatkauskas, Saulius;Perraut, Martine;Roussel, Guy;Aunis, Dominique;Kapfhammer, Josef P;Bagnard, Dominique
Title: A PKC-dependent recruitment of MMP-2 controls semaphorin-3A growth-promoting effect in cortical dendrites
Is part of: PLoS ONE [elektroninis išteklius]. San Francisco: Public library of science, 2009, Vol. 4, iss. 4
Extent: p. 1-11
Date: 2009
Keywords: Axon;Guidance;Semaphorin;Matrix metalloproteinases;MMP;Protin kinase
Abstract: There is increasing evidence for a crucial role of proteases and metalloproteinases during axon growth and guidance. In this context, we recently described a functional link between the chemoattractive Sema3C and Matrix metalloproteinase 3 (MMP3). Here, we provide data demonstrating the involvement of MMP-2 to trigger the growth-promoting effect of Sema3A in cortical dendrites. The in situ analysis of MMP-2 expression and activity is consistent with a functional growth assay demonstrating in vitro that the pharmacological inhibition of MMP-2 reduces the growth of cortical dendrites in response to Sema3A. Hence, our results suggest that the selective recruitment and activation of MMP-2 in response to Sema3A requires a PKC alpha dependent mechanism. Altogether, we provide a second set of data supporting MMPs as effectors of the growth-promoting effects of semaphorins, and we identify the potential signalling pathway involved
Internet: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663036/pdf/pone.0005099.pdf
Affiliation(s): Biologijos katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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