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Type of publication: conference paper
Type of publication (PDB): Tezės kituose recenzuojamuose leidiniuose / Theses in other peer-reviewed publications (T1e)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Riauka, Mantas;Daugelavičius, Rimantas
Title: The effects of lipophilic compounds on multidrug resistance pumps in Jurkat and MX1 cells
Is part of: The vital nature sign [elektroninis išteklius] : 8th international scientific conference : abstract book. Kaunas : Vytautas Magnus university, 2014, [no. 8]
Extent: p. 82-82
Date: 2014
Abstract: Multidrug resistance membrane pumps is the major factor causing failure in cancer treatment when various chemotherapeutic agents are used. In this study Jurkat and MX1 type cells were used to determine the effects of tetraphenylphosphonium cations and ionophoric antibiotics nigericin and monensin on multidrug resistance pumps. DNA intercalating agent ethidium bromide was used as indicator to assess the efficiency of multidrug pumps. The results of this study suggest that lipophilic tetraphenylphosphonium cations upregulates the expression of multidrug resistance pumps, whereas the expression is downregulated by nigericin and monensin
Affiliation(s): Biochemijos katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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