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Type of publication: conference paper
Type of publication (PDB): Tezės kituose recenzuojamuose leidiniuose / Theses in other peer-reviewed publications (T1e)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Bartkuvienė, Violeta
Title: Synthesis of novel 2-aminothiazole derivatives
Is part of: The vital nature sign [elektroninis išteklius] : 8-th international scientific conference : abstract book. Kaunas : Vytautas Magnus university, 2014, [no. 8]
Extent: p. 100-100
Date: 2014
Keywords: Heterocycle;Synthesys;2-amino;Thiazole
Abstract: The aminothiazole ring system is a useful structural element in medicinal chemistry and has found broad application in drug development for the treatment of allergies,1 hypertension,2 inflammation,3 bacterial infection4 and HIV.5 2-Aminothiazoles are usually synthesized by the condensation of α-haloketones with monosubstituted thioureas.6 In view of this important biological activity of thiazole derivatives we have decided to investigate the conventional functionalisation reactions (sulfonylation, condensation) of amino group in different 2-aminothiazoles-carboxylates to gain access to the new potentially biologically active compounds7,8. The condensation reaction of substituted aldehydes with aminothiazole carboxylate give the N-alkylated imines. Sulfonylation of ethyl-2-amino-4-methylthiazole-5-carboxylate and ethyl-2-aminothiazol-4-yl)ethanoate proceseded successfully and were obtained in the same reaction mixture mono- and disulfonated derivatives
Affiliation(s): Biochemijos katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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