Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/38857
Type of publication: conference paper
Type of publication (PDB): Tezės kituose recenzuojamuose leidiniuose / Theses in other peer-reviewed publications (T1e)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Bartkuvienė, Violeta
Title: Synthesis of novel 2-aminothiazole derivatives
Is part of: The vital nature sign [elektroninis išteklius] : 8-th international scientific conference : abstract book. Kaunas : Vytautas Magnus university, 2014, [no. 8]
Extent: p. 100-100
Date: 2014
Keywords: Heterocycle;Synthesys;2-amino;Thiazole
Abstract: The aminothiazole ring system is a useful structural element in medicinal chemistry and has found broad application in drug development for the treatment of allergies,1 hypertension,2 inflammation,3 bacterial infection4 and HIV.5 2-Aminothiazoles are usually synthesized by the condensation of α-haloketones with monosubstituted thioureas.6 In view of this important biological activity of thiazole derivatives we have decided to investigate the conventional functionalisation reactions (sulfonylation, condensation) of amino group in different 2-aminothiazoles-carboxylates to gain access to the new potentially biologically active compounds7,8. The condensation reaction of substituted aldehydes with aminothiazole carboxylate give the N-alkylated imines. Sulfonylation of ethyl-2-amino-4-methylthiazole-5-carboxylate and ethyl-2-aminothiazol-4-yl)ethanoate proceseded successfully and were obtained in the same reaction mixture mono- and disulfonated derivatives
Internet: https://hdl.handle.net/20.500.12259/38857
Affiliation(s): Biochemijos katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

Show full item record
Export via OAI-PMH Interface in XML Formats
Export to Other Non-XML Formats


CORE Recommender

Page view(s)

95
checked on Jun 6, 2021

Download(s)

12
checked on Jun 6, 2021

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.